Autotransporter proteins of Escherichia coli

自转运蛋白是一类与细菌毒力特性（如粘附、侵袭和生物膜形成）相关的新型蛋白质。尽管如此，关于它们的功能作用的资料有限。本项目的目的是表征致病性大肠杆菌的几种自转运蛋白。这些蛋白对感染的可能贡献表明它们是菌株衰减和疫苗菌株构建的潜在目标。这些蛋白质中的许多也介导细菌聚集，因此是抑制这一过程的新药的靶标。该项目将与来自丹麦的知名合作伙伴一起实施，并将为旅游和技术发展提供机会。

Autoransporters are a novel class of proteins associated with bacterial virulence properties such as adhesion, invasion and biofilm formation. Despite this, limited information is available on their functional role. The aim of this project is to characterize several of the autotransporter proteins from pathogenic E. coli. The likely contribution of these proteins to infection suggests that they are potential targets for strain attenuation and vaccine strain construction. Many of these proteins also mediate bacterial aggregation and are therefore targets for novel drugs that inhibit this process. The project will be carried out with a high profile partner from Denmark and will provide opportunity for travel and technology development.