REGULATORY MOLECULES OF CENTRAL SYNAPSES

阐明调节突触形成的分子机制是理解神经连接、高级大脑功能和精神障碍的先决条件。在这里，我们证明了谷氨酸受体Glurδ2通过Cbln1与突触前神经毒素相互作用来介导小脑突触的形成。这些结果表明，系统蛋白质组学和功能突触形成分析的结合提供了有效的筛选负责突触形成和功能的分子，有助于脑神经药理学的发展。

Elucidation of molecular mechanisms that regulate synapse formation is prerequisite for the understanding of neural wiring, higher brain functions and mental disorders. Here, we show that glutamate receptor GluRδ2 mediates cerebellar synapse formation by interacting with presynaptic neurexins through Cbln1. These results suggest that the combination of systematic proteomics and functional synapse formation assays provide efficient screening of molecules responsible for synapse formation and function, contributing to the development of brain neuropharmacology.