Morphological development of the kidney – a paradigm for organogenesis.

该项目旨在阐明肾脏是如何发育的，成人正常功能是如何建立的，以及先天性肾脏畸形是如何发生的。它的目的是研究在分支形态发生程序中发现的一种数学模式，它决定了肾脏的发育。通过结合尖端的遗传学方法、形态分析和数学模型，该项目计划探索这种模式是如何建立的，它如何决定肾脏的发育，以及它是否构成了器官形成的核心古老机制。项目成果可能会增进对基本发育过程以及发育疾病和变异的理解。项目发现对于理解其他器官系统的发展也可能很重要。

This project aims to shed new light on how the kidney develops, how normal adult function is established and how congenital kidney malformations occur. It aims to investigate a mathematical pattern that has been discovered in the program of branching morphogenesis which dictates kidney development. By combining cutting-edge genetic approaches, morphological analysis and mathematical modelling, this project plans to explore how this pattern is established, how it dictates kidney development and whether it constitutes an ancient mechanism central to organ formation. Project outcomes may improve understanding of fundamental developmental processes and developmental disease and variation. Project findings may also be important for understanding the development of other organ systems.