Studies on the etiologic agent and pathogenesis of summer-type hypersensitivity pneumonitis

本文对夏季型过敏性肺炎（HP）的病原体和发病机制进行了研究。我们的结果如下。夏季型HP病原体的研究当将患者家中的真菌发病率与对照受试者家中的真菌发病率进行比较时，在夏季型HP患者的家庭环境中观察到皮肤毛孢酵母（一种关节孢子形成酵母）的广泛分布，而在正常对照受试者家中未观察到。孤立的T。皮肤对患者血清表现出高反应性。几乎所有的患者都对用T的培养滤液抗原的吸入激发有反应。皮肤。这些结果清楚地表明T.皮肤炎是夏型HP的病原体。T.皮肤溃疡是HP感染的一种新的疾病。夏季型HP发病机制的研究环境研究表明，夏季型HP多发生在老木屋中，T。在雨季后闷热的夏季，皮层菌会生长在家中潮湿的旧木头、地垫、床单或虎皮鹦鹉的粪便上。也就是说，日本的夏季型HP是一种病室综合征。对66例由T.并与472例正常健康受试者的结果进行比较。结果表明，HLA-DQW 3在患者中的频率增加，提示宿主因素在该病的发生中的重要性。

We studied the etiologic agent and pathogenesis of summer-type hypersensitivity pneumonitis (HP). Our results were as follows.i. Studies on the etiologic agent of summer-type HP When the incidence of fungi in patients' homes were compared with that in homes of control subjects, extensive distribution of trichosporon cutaneum, an arthro-spore forming yeast, war observed in home environments of patients with summer-type HP but not in homes of normal control subjects. The isolated t. cutaneum demonstrated high reactivity to the patients' sera. almost all patients responded to the inhalation challenge with the culture filtrate antigen of t. cutaneum. These results clearly indicate that T. cutaneum is an etiologic agent of summer type HP. HP induced by T. cutaneum is a new disease of HP groups.ii. Studies on the pathogenesis of summer-type HP. Environmental study revealed that summer-type HP tended to occur in the resident of old wooded houses, and that T. cutaneum grew on old damp wood, floor mats, bed clothes, or budgeriger droppings in their houses during muggy summer season following the rainy season. In other words, summer-type HP in Japan is a sick-house syn-drome. The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type HP induced by T. cutaneum, and the results were compared to those obtained from 472 normal healthy subjects. Our results showed an increase of the frequency of HLA-DQW3 in the patients, suggesting the importance of the host factors for the generation of this disease.