Pathological and epidemiological studies on the pathogenesis of B-cell lymphoma

这项研究的目的是显示长期炎症在B细胞淋巴瘤发展中的病因学重要作用。本文在1989年4月至1990年1月期间取得的主要研究结果如下：1.甲状腺淋巴瘤(1)染色体分析表明，甲状腺淋巴瘤可分为两组：一组表现数量异常，临床表现为甲状腺肿大较慢，血清中有抗甲状腺抗体。第二组表现为结构异常，如14Q+伴甲状腺肿快速生长，抗甲状腺抗体阳性率低。(2)ATL非流行区甲状腺淋巴瘤均为B细胞型，但肿瘤细胞中EB病毒基因组整合异常。我们现在正在对ATL流行区的桥本氏病和甲状腺淋巴瘤患者进行病理和免疫学研究。2.慢性结核性脓胸患者胸膜淋巴瘤的发生我曾提出慢性结核性脓胸在胸膜淋巴瘤的发生中起重要作用。1989年，我们在日本开展了胸膜淋巴瘤的全国性研究，结果如下：(1)患者年龄46~81岁(平均63岁)，男女之比为5.2：1；(2)所有患者均有20年以上的慢性结核性脓胸病史；(3)肿瘤细胞完全为B细胞型。我现在正在准备一项病例对照研究，以调查结核性脓胸患者发生胸膜淋巴瘤的危险因素。

The purpose of this study is to show an etiologically important role of long-standing inflammation for development of B-cell lymphoma. The main results of my study obtained during the period April 1989 to January 1990 are as follows: 1. Thyroid lymphoma (1) Chromosome analysis suggested that thyroid lymphoma could be divided into two groups: the first group showed numerical abnormalities with clinical features of relatively slow growing struma and presence of anti-thyroid antibodies in the serum. The second group showed structural abnormalities such as 14q+ with rapidly growing struma and low positive rate of antithyroid antibodies. (2) Thyroid lymphomas in ATL non-endemic area were exclusively of B-cell type, but integration of EB virus genomes in the tumor cells were exceptional in these tumors. We are now making pathological and immunological studies on the patients with Hashimoto's disease and thyroid lymphoma in the ATL endemic area. 2. Pleural lymphoma developing in the patients with chronic tuberculous pyothorax I had previously suggested an etiologically important role of chronic tuberculous pyothorax for development of pleural lymphoma. In 1989, we have carried out nation-wide study of pleural lymphoma in Japan, and the results were (1) the age of patients ranged from 46-81 years(mean 63 years) with a male to female ratio of 5.2:1, (2) all patients had over 20 years history of Chronic tuberculous pyothorax, (3) tumor cells were exclusively of B-cell type.From the findings shown by us and other investigators it is suggested that B-cell lymphoma could evolve in the tissue affected by chronic inflammation of autoimmune or non-autoimmune nature. I am now preparing case-control study to investigate risk factor for development of pleural lymphomas among the patients with tuberculous pyothoiax.