Effects of recombinant human superoxide dismutase and 2-0-octadecylascorbic acid on survival of tumor bearing mice and on side effects of bleomycin and adriamycin

与未处理的小鼠相比，皮下（SC）注射100 mg/kg重组人超氧化物歧化酶（rSOD）或15 mg/kg 2-0-十八烷基抗坏血酸（CV-3611）3次，可显着延长藤本腹水荷瘤小鼠的平均生存时间（MST）（rSOD：11.94 <plus-minus>0.34 vs. 9.88 <plus-minus>0.33天，p&lt;0.001 ; CV-3611：13.58 <plus-minus>1.82 vs. 9.78 <plus-minus>0.19天，p&lt; 0.05）。小鼠<plus-minus>腹腔注射博莱霉素（BLM）75 mg/kg 3次，MST为22.00 ± 1.44天。120 <plus-minus>mg/kg博莱霉素ip 3次后，其存活时间为11.36 ± 0.80 d，而<plus-minus>120 mg/kg博莱霉素ip + mg/kg rSOD sc 3次或120 mg<plus-minus>/kg博莱霉素ip +15 mg/kg CV-3611 sc后，其存活时间分别为16.79 ± 2.47 d和16.86 ± 2.70 d。e.腹腔注射阿霉素3 mg/kg 6次可引起心肌收缩带坏死、牵拉、嗜酸性变性和心内膜炎，腹腔注射阿霉素3 mg/kg联合rSOD 30 mg/kg sc 6次或CV-3611 sc 5 mg/kg可减轻上述病理变化。

The mean survival time (MST) of Fujimoto ascites tumor-bearing mice was significantly prolonged by subcutaneous (sc) injection of 100 mg/kg recombinant human superoxide dismutase (rSOD) or 15 mg/kg 2-0-octadecylascorbic acid (CV-3611) 3 times, compared to untreated mice (rSOD : 11.94 <plus-minus> 0.34 vs. 9.88 <plus-minus> 0.33 days, p<0.001 ; CV-3611 : 13.58 <plus-minus> 1.82 vs. 9.78 <plus-minus> 0.19 days, p< 0.05). The MST was 22.00 <plus-minus> 1.44 days in mice intraperitoneally (ip) given 75 mg/kg bleomycin (BLM) 3 times. It decreased to 11.36 <plus-minus> 0.80 days in mice given 120 mg/kg BLM ip 3times but it was significantly (p < 0.05) higher (16.79 <plus-minus> 2.47 days) in those given both 120 mg/kg BLM ip and mg/kg rSOD sc 3 times or (16.86 <plus-minus> 2.70 days) both 120 mg/kg BLM ip and 15 mg/kg CV-3611 sc. Pneumomia, degenerated liver, and atrophic salivary glands were seen in mice given BLM, but these pathological change were milder in mice given BLM combined withPathological findings indicating cardiotoxicity, i. e. contraction band necrosis, stretching, eosinohpilic degeneration of cardiac muscles and endocarditis, were seen in mice given 3 mg/kg adriamycin ip 6 times, these pathological changes were milder in mice given 3 mg/kg adriamycin ip combined with 30 mg/kg rSOD sc 6 times or 5 mg/kg CV-3611 sc.