Correlations between Lefestyles and Mental- or Physical Health Status

1.在日本工人中，吸烟等生活方式。方法：1.采用问卷调查和体检资料，对饮酒、自评压力、体育锻炼、人格和生活质量等心理健康状况、身体健康状况进行综合测量。检测同一受试者外周血淋巴细胞姐妹染色单体互换(SCE)和染色体畸变率(CA)。与生活方式差的人相比，生活方式好的人姐妹染色单体交换频率和Ara-C对CA频率的增高率较低。用聚合酶链式反应方法检测低Km ALDH2的基因分型。缺乏ALDH2的习惯性饮酒者的姐妹染色单体交换频率显著高于非习惯性饮酒者和具有ALDH2活性的非习惯性饮酒者。一般来说，饮酒行为受到ALDH2活性的强烈调控。生活方式良好的人的自然杀伤(NK)活性明显高于生活方式不佳的人。淋巴细胞亚群的比例也与良好的生活方式相关。较高的总IgE水平与生活方式显著相关，尤其与吸烟和饮酒有关。

1. In Japanese workers, lifestyles such as smoking. drinking, self-reported stress, physical exercise, mental health status including character and quality of life, and physical health status were comprehensively measured using questionnaires and physical examination data.2. In the same subjects, frequencies of sister-chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes were measured. Those who have good lifestyles had lower frequencies of SCE and lower enhancement ratios of CA frequencies by ara-C, compared to those with poor lifestyles. Genotypes of low Km ALDH2 were determined by the PCR method. Habitual drinkers who lack ALDH2 had significantly higher SCE frequency than non-habitual drinkers who lack ALDH2 or those who possess ALDH2 activity. Generally, alcohol-drinking bahaviors were strongly regulated by the ALDH2 activity.3. Natural killer (NK) activities were significantly higher in those with good lifestyles than those with poor lifestyles. Proportions of subsets of lymphocytes were also correlated with good lifestyles.4. Higher total IgE levels were significantly correlated with lifestyles, especially with smoking, and alcohol consumption.