Experimental study on the transcatheter proximal arterial occlusion maintaining the blood supply to the distal organs.

（1）自体灌注球囊导管维持远端器官血供的实验研究：a）通过血管模型和透析泵循环甘油溶液，测量每分钟通过侧孔的溶液量。结果。结果表明，具有3-5个直径为0.8-1.3sm的侧孔的APBC最适合于APBC，因为这些侧孔可以通过足够量的甘油溶液，并且可以有效地冲洗并且不会扭结。通过7 F的甘油溶液的量。B）一年后，我们将APBC插入狗的上级肠系膜动脉，并试图研究通过近侧孔的外周动脉血流。但APBC在相对较短的时间内被血栓闭塞。因此，我们认为上级肠系膜动脉不适合本实验研究 ...更多信息 将气囊导管（APBC）插入七只狗的肾动脉中约两个半小时。腹部造影显示肾动脉血流被APBC阻塞。肉眼和显微镜检查显示切除标本无显著变化。它的结论是，APBC是有用的情况下，近端动脉闭塞，维持血液供应的远端器官相对较短的时间，它可以用于治疗动脉破裂，饲料的关键器官。（2）含氧人工血疗效的实验研究：用普通球囊导管阻断5只犬肾动脉，用注射器以不同速度注入含氧人工血（全氟化学乳剂）2 h。然后我们将它们纯化，并对闭塞的肾脏进行肉眼和显微镜检查。结果表明，当以20 ml/h/kg以上的速度注射全氟乳剂时，肉眼和显微镜检查未发现显著变化。该注射速度被认为是近端动脉闭塞所需的最低速度，其可以通过全氟化学乳剂维持远端器官的氧气供应。少

(1)Experimental study on the usefulness of the autoperfusion balloon catheter in maintaining the blood supply to the distal organs :a)We circulated glycerin solution by means of the vessel model and the pump for dialysis, and we measured the amount of the solution passing through the sideholes per a minute. As a result. it can be concluded that APBCs with 3-5 sideholes of 0.8-1.3sm in diameter are most suitable for APBC, because these can pass sufficient amount of glycerin solution and can be flushed effectively and do not kink. The amount of glycerin solution which pass through 7F. APBC with 3 sideholes of 1.3mm in diameter was 129ml/minute.b)Following the previous year, - we inserted APBCs into the superior mesenteric arteries of the dogs and tried to investigate peripheral arterial flow through the proximal sideholes. But APBC was occluded by thrombi in relatively short periods. So we thought that superior mesenteric artery is not suitable for our experimental study.c)Autoperfusion … More balloon catheters(APBC)were inserted into the renal arteries of seven dogs for about two and a half hours. Abdominal aortography showed renal arterial flow of the kidney obstructed by APBC. Macroscopic and microscopic examination revealed no significant changes in the resected specimen. It is concluded that APBC is useful in cases of the proximal arterial occlusion by maintaining the blood supply to the distal organs for relatively short periods and that it can be used for the treatment of rupture of arteries which feed critical organs.(2)Experimental study on the efficacy of oxygenated artificial blood :We occluded renal arteries of five dogs by ordinary balloon catheter, and injected oxygenated artificial blood(perfluorochemical emulsion)at various speed for two hours by injector. Then we sacrified them and examined the occluded kidney macroscopically and microscopically. The result was that when we injected perfluorochemical emulsion at such a speed as more than 20ml/hour/kg. no significant changes could be revealed on macroscopic and microscopic examination. This injection speed was thought to be the lowest speed which was necessary for the proximal arterial occlusion which can maintain the oxygen supply to the distal organs by perfluorochemical emulsion. Less