Development of next generation ventricular assist system and study of long-term assisted circulation

我们已经开发了一种植入式左心室辅助系统（LVAS）的小型成人患者。泵由多段聚醚聚氨酯制成，为气动隔膜式，设计定位于左腹壁。其中9只在4 ~ 18周后在身体状况良好的情况下被处死。为了实现充分的监测和自动控制，开发了基于电阻抗的监测和控制系统（Z系统）。植入泵的性能得到了很好的监测，Z系统很好地控制了满充至满空驱动。总之，该LVAS具有临床应用前景。

We have developed an implantable left ventricular assist system (LVAS) for small sized adult patients. The pump made of segmented polyether poly-urethane was pneumatic driven diaphragm type, which was designed to be positioned in the left abdominal wall. Nine of them were sacrificed after 4 to 18 weeks in good physical condition. The electrical impedance-based monitoring and control system (Z system) was developed for adequate monitoring and automatic control. The performance of the implanted pump was well monitored and the full-fill to full-empty drive was well controlled by the Z system. In conclusion, this LVAS is promising for clinical use.