Bioinks that Advance 3D bioprinting of cells to the 4th dimension
Bioinks that Advance 3D bioprinting of cells to the 4th dimension
批准号:
LP210200868
负责人:
Prof John Gooding
金额:
$35.98万
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2023
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2023-02-01 至 2026-01-31
中文摘要
本研究的目的是提供一种简单的方法,用于使用3D打印创建复杂的3D细胞培养物,用于体外细胞检测。一种多功能聚合物系统,作为一种生物墨水,完全由商业上可用的组件制成,将被推进,提供全方位的软组织模拟,并可以在3D细胞培养物打印后按需动态改变。后者将提供体内事件的体外模拟,以前从未有过更现实的体内发现的模型。应用于基础细胞生物学,研究疾病和开发新药。这项研究的结果将是设计廉价的细胞外基质模拟物和高通量3D细胞分析的新知识。
英文摘要
The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vivo events never previously possible with more realistic models of what is found in vivo. Applications are in fundamental cell biology, studying diseases and developing new drugs. The outcomes from this research will be new knowledge on designing cheap extracellular matrix mimics and high throughout 3D cell assays.
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