Totally Implantable Artificial Heart & Its Hemocompatibility

本次国际合作研究的目的是通过合作实验研究、交流科学思想、探讨技术课题，开发完全植入式人工心脏，提高人工心脏的血液相容性。现将该技术的进展情况报告如下：全植入式人工心脏部件的基础研究与开发。开发了一种电液全人工心脏，并对泵系统的输出性能和效率进行了改进。另一种独特的全人工心脏由一个离心泵和两个三通阀组成。在模拟回路中对一种机电人工心脏进行了评价。并进行了移动致动器型全人工心脏的研究开发。经皮能量传递系统和内部电池也进行了研究。在血泵方面，我们进一步研究了双肢形和水母形瓣膜作为人工瓣膜的应用，并研究了囊形泵和离心泵的血室结构。人工器官血液相容性的基础研究及其在血泵中的应用。对血泵的抗血栓性进行了改进。它们是抗血栓形成聚氨酯的开发，混合组织生物工程技术的应用，内皮细胞在聚氨酯片上的细胞外基质上播种，以及在血泵表面固定化蚓激酶。基础研究活动为全人工心脏和左心室辅助装置中组织因子途径抑制剂、蛋白和钙吸附表面的分子生物学研究。人工心脏的性能评价。将电液全人工心脏和离心泵应用于实验动物，证明了其在体内的良好性能。在犊牛和绵羊体内植入了一种移动致动器型人工心脏。少

The purposes of this international cooperative study are to develop totally implantable artificial hearts as well as to improve hemocompatibility of such devices through cooperative experimental study and exchanging scientific ideas, and discussing technological subjects.Progresses of the technology were reported as below ;1.Basic research and development of components of a totally implantable artificial heart.An electrohydraulic total artificial heart was developed and improvements of output performance and efficiency of the pump system was carried out.Another unique total artificial heart was also developed composed of a single centrifugal pump and 2 three-way valves.An electro-mechanical artificial heart has been evaluated in a mock loop.Research development of a moving-actuator-type total artificial heart was also conducted.A transcutaneous energy transfer system and internal batteries were also investigated.Concerning blood pumps, bileaflet-type and jellyfish-like-shaped valves we … More re studied for application as artificial valves, and configuration of blood chambers of a sactype pump and a centrifugal pump was studied.2.Basic research in hemocompatibility of artificial organs and its application to blood pumps.Improvements of antithrombogenicity of a blood pump were carried out.They were development of an antithrombogenic polyurethane, application of a bioengineering technology of hybrid tissues, endothelial cell seeding onto extracellular matrix on polyurethane sheets, and lumbrokinase-immobilization on the surface of a blood pump.basic research activities were molecular biological studies on tissue factor pathway inhibitor and protein and calcium adsorption of the surface in a total artificial heart and a left ventricular assist device.3.Evaluation of the performance of artificial hearts.An electrohydraulic total artificial heart and a centrifugal pump were applied to experimental animals and satisfactory in vivo performances were proved.A moving-actuator-type artificial heart was implanted in calves and sheep. Less