Study of the proper management of total liquid ventilation and the development of the system for respiratory suport

1.初步研制了一种容量控制、限压模式的液体呼吸机，并在兔上进行了全液体呼吸机的实验研究。结果：1.实验初期全液体通气时呼气末残气量(EERV)过大，与用其他方法测得的全氟碳压力-容量曲线相比，EERV过大。用兔进行体重控制的全液体通气法。这种通风调节潮气量和EERV的原理如下：PFC密度大，液体通风动物的体重不同。因此，如果控制了最大重量和最小重量，则可以控制TV和EERV。液体换气时EERV增加，TV和换气周期不变。PaO2、SaO2和Hb浓度无明显变化，而PaCO2和SvO2随EERV增加而恶化。也就是说，EERV Damage…增加S更多的是气体的交流和循环。EERV的生理水平最高的是液体的功能性剩余容量(FRC of Liquid：FRCL)。然而，要在较短的时间内达到ERCL的EERV是非常困难的。PFC的失效需要拉力，因为它的反冲性能很低。对于虹吸式等传统的保质期，在保质期内会出现低谷。这些低谷似乎是由呼吸道阻塞引起的，这可能会导致呼吸道出血或换气不均匀。我们开发了一种新的呼气方法，其中虹吸的差值随着呼气的增加而迅速减小。通过这种方法，相当平稳的保质期变得可行。在EERV降为FRCL，TV恒定小容量，但通气量变化的条件下，用该方法对兔进行全液体通气法。PaO_2和PaCO_2无代谢性酸中毒。兔全液体呼吸机不可能同时保持PaCO_2和SvO_2的生理性。研究证明，在兔等疑难病例中维持全液体通气量是有可能的，其结果可能否定传统的全液体通气量的观点：全液体通气量必须维持在大TV和小通气率。较少

1. Initially, a liquid ventilator was developed which was controlled by volume-controlled with pressure limit mode, and total liquid ventilation was performed with it in rabbits. End-expiratory residual volume (EERV) was proved too excessive during total liquid ventilation at initial experiment when compared with the pressure-volume courve of perfluorocarbon measured with others rabbits.2. Weight-controlling total liquid ventilation with rabbits was carried out. The principal of this ventilation to regulate a tidal volume and the EERV was as follows ; the density of PFC is large and the weight of a liquid ventilated animal varies. Therefore, if a maximum and minimum weight are controlled, it follows that a TV and EERV can be controlled. The EERV was increased during liquid ventilation, but TV and ventilation cycle were kept the same. There was no change in PaO2, SaO2, and hemoglobin concentration, whereas PaCO2 and SvO2 deteriorated as the EERV increased. That is, increase in EERV harm … More s gas exchange as well as circulation. The most physiological level of the EERV was around functional residual capacity of liquid (FRC of liquid : FRCL).3. However, to reach the EERV of ERCL with relatively short time was very difficult. Expiration of PFC needs drawing force due to low recoil property. With conventional expiration such as siphon, troughs appear during expiration. These troughs seem to be caused by airway occlusion which may cause airway bleeding or uneven ventilation. We developed a new expiratory method in which difference for siphon became rapidly smaller as the expiration. Rather smooth expiration became feasible with the method.4. Total liquid ventilation with rabbits was carried out with this method on the condition that the EERV was lept as FRCL and a TV was kept constant small volume, but ventilation rate varied. The PaO2 and PaCO2 improved rate-responsively without metabolic acidosis.5. Total liquid ventilation with rabbits was considered that it was impossible to keep both PaCo2 and SvO2 physiologically. The research proved that there was a possibility that the total liquid ventilation could be maintained in difficult cases such as rabbits, and that the results might deny the conventional view for total liquid ventilation : total liquid ventilation must be maintained with large TV and small rate. Less