Bioactivity of materials provided by ultrasonic implantation

超声波植入技术用于提供具有生物活性的生物相容性基质，其中通过超声波能量搅拌生物活性玻璃悬浮液以将玻璃颗粒植入基质表面。将CaSiO_3玻璃植入聚甲基丙烯酸甲酯（PMMA）基板中，超声振动可使具有生物活性的CaSiO_3玻璃颗粒悬浮在最佳悬浮溶液40thf -60乙醇中，以微观不均匀的形式植入表面。这种不均匀性被认为是由于超声能量分布不均匀造成的。在强化区基底上发现了四层：玻璃颗粒(40mum) -PMMA (60mum) -玻璃颗粒(40mum) -PMMA。在低能区观察到两层：玻璃粒子(40mum) -PMMA。在这两个区域中，最大表面的PMMA密度较低，因此所使用的模拟体液（Kokubo溶液）可以穿过玻璃颗粒上的层，参与磷灰石形成。我们找不到一种能使硅橡胶表面膨胀的最佳溶剂，因此采用了一套两种在室温下硫化的硅橡胶前驱体。在两种液体混合后凝胶化的过程中，用CaSiO_3玻璃颗粒悬浮乙醇进行超声植入。当植入的衬底在SBF中浸泡仅一天时，观察到玻璃的均匀植入以及磷灰石层的沉积。超声可植入溶胶-凝胶衍生二氧化硅颗粒悬浮液和气相二氧化硅胶体，但不能在基体上沉积磷灰石层。这是由于这些颗粒的生物相容性。

Ultrasonic implantation technique was employed to provide biocompatible substrates with bioactivity where a suspension of a bioactive glass was agitated by an ultrasonic energy to implent the glass particles into the substrate surfaces.a.CaSiO_3 glass into poly (methyl methacrylate) (PMMA) substratesThe ultrasonic vibration could implant the bioactive CaSiO_3 glass particles into the surface in microscopic inhomogeneity when suspended in an optimum suspending solution 40THF-60ethanol. The inhomogeneity was considered to be caused by inhomogeneously distribution of the ultrasonic energy. In the intensified region four layrs were found on the substrate : the glass particles (40mum) -PMMA (60mum) -glass particles (40mum) -PMMA.In the lesser energy region two layrs were observed : glass particles (40mum) -PMMA.In either regions the PMMA on the utmost surface had lower density hence the simulated body fluid (Kokubo solution) used could go through the layr to be involved in apatite formation on the glass particles.b.CaSiO_3 glass into sillicone rubber substratesWe could not find such an optimum solvents that can swell up the surface of sillicone rubber and thus employed a set of two precursors for silicone that vulcanize at the room temperature. On the way of gelation after mixing the two liquids the ultrasonic inplantation was carried out with CaSiO_3 glass particles suspended ethanol. Homogeneous implantation of the glass was observed as well as the deposition of an apatite layr when the implanted substrate was soaked in the SBF for only a day. The suspensions of sol-gel derived silica particles and fumed silica colloid could be ultrasonically implanted but the apatite layr could not deposit on the substrates. This was attributed to the biocompatible character of those particles.