Assessment of the effectiveness of cancer therapy using PET.

形态学成像策略，如平片、X线CT、MRI和超声检查已被用于评价癌症治疗。比较两组治疗前后肿瘤形态、直径的变化。偶尔，我们会遇到治疗后没有存活肿瘤细胞的残留肿块的病例。并且有许多病例即使在治疗后我们不能识别残留肿块，也会出现早期复发。形态学方法在肿瘤治疗评价中的作用有限，FDG-PET已被公认为是肿瘤学中有用的诊断工具。我们将FDG-PET研究应用于肿瘤治疗的评估，并与形态学方法进行比较。对15例非小细胞肺癌患者在放疗前、放疗中、放疗后进行了连续三次FDG-PET检查。在每例患者的三次扫描中比较肿瘤的FDG积聚。通过X线平片或CT测量的肿瘤大小缩小 ...更多信息 大部分患者治疗后的血糖水平与FDG蓄积有关。结果表明，FDG-PET对肿瘤细胞的数量和代谢活性的信息存在差异，本文对肿瘤的细胞结构和部分容积效应进行了研究，作为肿瘤摄取FDG的基础研究。本文对37例疑有复发的直肠癌患者进行了FDG PET检查，探讨了肿瘤大小与FDG摄取的相关性。在几个受试者的组织病理学检查中观察到的细胞结构进行比较FDG积累。结果表明，肿瘤大小与摄取量呈正相关.这表明，肿瘤的大小应考虑到准确估计FDG摄取。有细胞和FDG摄取之间的相关性。FDG-PET用于评价治疗效果时，FDG的蓄积取决于残留肿瘤细胞的数量，FDG-PET能够提供常规形态学诊断成像技术所不能提供的新信息。FDG-PET是评价肿瘤治疗效果的有效方法。少

Morphologiacal imaging strategies such as plain radiography, X-ray CT,MRI and ultrasonography have been used for the evaluation of cancer treatment. The shape and diameter of tumor are compared before and after the treatment. Occasionally, we meet the cases of residual mass without viable tumor cells after the therapy. And there are many cases of early recurrent disease even if we could not identify the residual mass just after the treatment. Morphological approach has limited ability in the assessment of cancer therapy.FDG-PET has been accepted as a useful diagnostic tool in oncology. We applied FDG-PET study to the assessment of cancer treatment and compared with the morphological methods. Three consecutive FDG-PET studies before, in the middle of and after the radiation therapy were performed in fifteen patients with non-small cell lung carcinomas. FDG accumulation to the tumors were compared in three scans of each patient. Reduction of tumor size measured by plain radiography or CT … More after the treatment was correlated to FDG accumulation in most of the patients. However, there were some patients without agreement between morphological study and FDG-PET.These results suggest that FDG-PET has different information on the number of tumor cells and metabolic activity.Cellularity of the tumor and partial volume effect were studied, as a basic study of FDG uptake to tumor. Thirty-seven patients with suspected recurrent disease of rectal cancer were studied with FDG-PET.Correlation between the size of tumors and the FDG uptake was studied. FDG accumulation was compared to cellularity observed in histopathological examinations in several subjects. Positive correlation was found between the size and the uptake. This suggests that the size of the tumor should be taken into consideration for accurate estimation of FDG uptake. There was a correlation between cellularity and FDG uptake. When FDG-PET is used for the evaluation of therapy, the accumulation of FDG is considered to be dependent on the number of residual tumor cells.FDG-PET is able to provide new information, which could not be obtained by conventional morphological diagnostic imaging technique. FDG-PET is aeffective method for the assessment of cancer therapy. Less