Titanium Surface Modification with Ion Beam Mixing Method for Implant Use -Influence of Solubility of Thin Calcium-phosphate Coatings on Cell Behavior-

为了克服等离子喷涂法制备钙磷膜的缺点，采用离子注入与物理气相沉积相结合的离子束动态混合法制备了钙磷膜，制备出了一种薄而粘接、无缺陷的钙磷膜。在钛（Ti）基板上涂覆薄涂层（约1微米），然后用传统的炉加热和激光辐射和红外辐射的快速加热进行热处理。x射线衍射分析表明，未经处理的薄膜为无定形，但在500个炉内加热和高于600个炉内红外辐射快速加热后，薄膜变为结晶。研究了涂层在模拟体液中的溶解度、与Ti衬底的粘附性以及涂层与Ti衬底界面处的x射线光电子能谱分析。(1)未处理的薄膜在1天内溶解。(2)在500℃的炉内加热时，涂层出现裂纹。x射线光电子能谱分析表明，涂层与Ti基体界面处的裂纹是由于ca注入层数减少和Ti- p化合物生长过多所致。(3)激光辐照涂层易溶解，表面降解不均匀。(4)红外辐射控制了Ca-P的溶解度，保证了涂层对基体的附着力。在600-700℃的红外辐射下，涂层溶解最小。利用大鼠骨髓进行成骨样细胞培养试验。扫描电镜观察发现，与钛表面和可溶性钙磷涂层相比，不溶性（结晶）钙磷涂层形成了细胞外基质。

In order to overcome a shortcoming of Ca-P coatings with the plasma spraying method, thin calcium-phosphate (Ca-P) coatings were produced by the ion beam dynamic mixing method which combined ion implantation and physical vapor deposition, resulting a thin, adherent and defect-free film. Thin coatings (approximately 1 mum) were coated onto titanium (Ti) substrates, followed by heat-treatment with conventional furnace heating and rapid heating of laser radiation and infrared radiation.1. X-ray diffraction analysis revealed untreated films to be amorphous but to become crystalline after furnace heating at 500ﾟC and rapid heating with infrared radiation higher than 600ﾟC.2. Solubility of coatings in simulated body fluid, adherence to Ti substrate, and X-ray photoelectron spectroscopy analysis at the interface between the coating and the Ti substrate were investigated. (1) Untreated films dissolved within 1 day. (2) Cracks were observed in coatings with furnace heating at 500ﾟC.X-ray photoelectron spectroscopy analysis at the interface between the coating and the Ti substrate showed that cracks were the result of decreased Ca-implanted layrs and too much growth of Ti-P compounds. (3) Coatings with laser radiation tended to dissolve easily with non-uniform surface degradation. (4) Infrared radiation controlled the Ca-P solubility and ensured the adherence of the coatings to the substrate. Coatings with infrared radiation at 600-700ﾟC dissolved minimally.3. Cell culture test carried out with osteoblast-like cell using the rat bone marrow. SEM observation showed extracellular matrix formation on insoluble (crystallized) Ca-P coatings compared to on titanium surface and on soluble Ca-P coatings.