Functional Brain Mapping using 3D Positron Emission Tomography and functional Magnetic Resonance Imaging

本研究的目的是利用三维正电子相机（PET）和功能磁共振成像（fMRI）建立一种功能脑成像方法。使用并行处理算法和日本东北大学超级计算机（SX4, NEC inc ., Japan） （Ann nuclear Med, 1997）实现了快速3d图像重建（每63片数据块1分钟）。在注射^<15>标记水后进行3d动态数据采集，无需动脉采血即可计算绝对脑血流量（J Cereb blood flow metabolism, 1996）。受试者的辐射暴露可减少到通常二维数据采样的1/10^< >（《核医学杂志》，1997）。利用仿射线性图像变换到模板PET图像集，开发了解剖脑标准化软件。通过对比20张日本和20张英国的脑图像，测试了该系统和SPM96的准确性，发现如果采用非线性变换，该系统的转换是成功的。若干临床研究使用该系统进行PET和fMRI（神经外科精神病学，1997；J Intl Soc生命信息科学，1997;Am J Neuroradiol, 1997）

The aim of this study is to establish a functional brain mapping approach using 3-D positron camera (PET) and functional magnetic resonance imaging (fMRI). A rapid 3D-image reconstruction (1 min per a block data of 63 slices) was achieved using parallel processing algorithm and Tohoku University Super Computer (SX4, NEC inc, Japan), (Ann Nucl Med, 1997). 3D-dynamic data acquisition after injection of ^<15>O labeled water enabled absolute cerebral blood flow calculation without arterial blood sampling (J Cereb Blood Flow Metabol, 1996). Radiation exposure to subjects could reduced to 1/10^<th> of usual 2D data sampling (J Nucl Med, 1997). Anatomical brain standardization software was developed using affine linear image transformation to a template PET image set. Accuracy of this system and the SPM96 was tested by comparing 20 Japanese and 20 British brain images and found that transformation was successful if non-linear transformation was applied. Several clinical researches were carried out using this system for PET and fMRI (Neurosurg Psychiat, 1997 ; J Intl Soc Life Info Sci, 1997 ; Am J Neuroradiol, 1997)