気管支喘息の気道傷害後の修復とリモデリングにおける成長因子の役割-特にトランスフォーミング成長因子β(TGFβ)を中心に-

我们研究了多种生长因子在调节哮喘气道粘膜修复和重塑过程中的潜在作用。在气道局部环境中可能积累的生长因子中，转化生长因子-β-1（TGF β-1）对人支气管上皮细胞的增殖显示出强有力的抑制作用。Th 1-T细胞衍生的淋巴因子干扰素γ也显示出对细胞生长的抑制作用。此外，TGF β-1，而不是干扰素-γ，具有抑制作用的人气道上皮细胞的纤毛分化的空气-液体界面培养的体外模型评估。通过半定量逆转录和聚合酶反应技术评估，TGF β-1基因表达的幅度在从气道炎症性疾病（包括哮喘）患者获得的qpithelium中上调。已报道TGF β-1刺激气道成纤维细胞产生胶原和细胞外基质。总之，它可能在气道的修复和重塑反应中发挥重要作用。

We investiqated the potential role of a variety of growth factors in the regulation of mucosal repair and remodelling processes in the airways of asthma. Among growth factors ppssibly accumulated in the local environments of the airways, transforming growth factor-beta-1(TGFbeta-1)showed a potent inhibitory effect on the proliferation of human bronchial epithelial cells. A Th1-T cell-derived lymphokine interferon gamma also showed an inhibitory action on the cell growth. Moreover, TGFbeta-1, but not interferon-gamma, had a suppressive effect on the ciliated differentiation of human airway epithelial cells as assessed by an in vitro model of air-liquid interface culture. The megnitude of TGFbeta-1 gene expression was uprehulated in the qpithelium obtained from patients with airway inflammatory disorders including asthma as evaluated by a semiquantitative reverse transcription and polymerase reaction technique. TGFbeta-1 has been reported to stimulate airway fibroblasts to produce collagens and extracellular matrices. Taken together, therefore, it may play an important role in the repair and remodelling responses of the airways.