Role of serum PAF acctylhydrolase on atherosclerosis

血小板活化因子（PAF）乙酰水解酶是PAF的灭活剂。血清PAF乙酰水解酶由脂蛋白携带，主要由低密度脂蛋白（LDL）携带，并能从氧化的LDL中释放溶血磷脂酰胆碱。因此，PAF乙酰水解酶可能在脂质代谢和动脉粥样硬化的形成中起作用。利用PAF乙酰水解酶缺陷患者血清，结果表明，PAF乙酰水解酶缺陷型血清对铜氧化的敏感性较低。普罗布考或干扰素使血清PAF乙酰水解酶活性升高。这些结果表明PAF乙酰水解酶在脂质代谢中起一定作用，并受药物的调节。PAF乙酰水解酶对动脉粥样硬化的直接作用有待于进一步的体外实验研究。

Platelet activating factor (PAF) acetylhydrolase is known as an inactivator of PAF.Serum PAF acetylhydrolase is carried by lipoproteins, mainly by low density lipoprotein (LDL), and it is known to release lysophosphatidylcholine from oxidized LDL.Therefore, it is possible that PAF acetylhydrolase play roles on lipid metabolism and formation of atherosclerosis.Using serum of PAF acetylhydrolase deficient patient, it was revealed that PAF acetylhydrolase deficient serum was less susceptible to oxidation by copper. And probucol or interferon made serum PAF acetylhydrolase activity higher than control. These results indicate that PAF acetylhydrolase play some roles on lipid metabolism and is regulated by some drugs. Futher in vitro experiment is necessary to evaluate the direct effects of PAF acetylhydrolase on atherosclerosis.