A study to develop homeostatic biomaterial

与连接上皮相比，种植体周围上皮可能具有较少的半粒间体附着，并且维持较低的增殖防御机制的能力。宫颈液体流动可能有助于种植体周围上皮的低增殖活性。对于某些类型的种植体，了解种植体放置后早期肉芽和骨愈合如何发生，以及从种植体表面到核心种植体的距离如何影响愈合，对于优化种植体表面几何形状至关重要。在超微结构上，骨-钛界面存在由细小的原纤维状结构组成的矿化不良层或通过薄无定形带（20-40nm）形成的细长细胞层。该无定形区对对蛋白聚糖具有高亲和力的乌红呈阳性，这可能是细长的细胞层、矿化程度较差的层或成熟骨与钛之间的附着所必需的。研究表明，4-META进入牙髓后，大部分被穿透的4-META在牙髓表面形成STHL，残留物深入牙髓组织形成未成熟聚合物。剩余未聚合的MMA单体、4meta单体、丁醇和硼酸到达渗透前沿。当4-META应用于牙髓时，这些现象可能导致血流减少，扰乱牙髓早期愈合。从现在开始，我们将尝试生产出更厚的软组织混合层的新材料。

1 : A Study of implant-tissue interfaceThe peri-implant epithelium may have less hemidesmosomal attachment and maintain lower capacity to act as a proliferative defense mechanism than does the junctional epithelium. Cervicular fluid flow may help the low proliferative activity of the peri-implant epithelium.With some implant types, an understanding of how early granulation and bone healing occurs following placement of the implant, and how healing can be influenced by the distance from the implant surface to core implant, is crucial to optimizing implant surface geometry.Ultrastructurally, bone-titanium interface there are poorly mineralized layr consisting of delicate fibril-like structures or the slender cell layr through a thin amorphous zone (20-40nm). This amorphous zone was positive for uthenium red which has a high affinity for proteoglycans and this may be an essential for attachment between the slender cell layr poorly mineralized layr or mature bone and titanium.2 : Develop homeostatic biomaterialIt is suggested that, after 4-META penetration into the pulp, most of the penetrated 4-META forms STHL at the surface area of pulp, and the residue penetrates deep into pulp tissue to form and immature polymer. The remaining unpolymerized MMA monomer, 4 META monomer, butanol, and boric acid reach the front edge of penetration. These phenomena might cause decrease of blood flow and may disturb the early stage of pulpal healing when 4-META is applied on the pulp.From now on we will try to produce new material which produce much more thicker soft tissue hybrid layr.