A study on a signal mechanism of Malasse's epithelial rests of homeostasis in periodontal ligament

本项目的目的是阐明Malassez上皮细胞REST的信号转导机制。1998年，我们报道了Heltwiz上皮根鞘断裂的机制和Malassez上皮剩余部分的增殖机制。1999年，我们也报道了间充质细胞可以在破碎的上皮鞘之间迁移并附着在内釉上皮上，间充质细胞从内釉上皮接收到一些信号，然后分化为成牙骨质细胞。2000年，研究了牙根上皮残留在粘固剂中的过程，随着牙根形成的推进，部分上皮簇的基底膜再生，并作为牙周膜上皮残留在牙周韧带中。另一方面，基底膜的再生受阻于与间充质细胞接触的结果，它们通过成牙骨质细胞的底物沉积嵌入到骨水泥中。细胞死亡是由于基底膜的再生不进行，牙骨质基质包裹了基底膜而引起的，提示临床上丢失的牙周组织，尤其是牙骨质的再生，来自Malassez上皮静息的信息是很重要的。通过从剩余牙周组织的上皮细胞发出信号，牙周膜分化为成牙骨质细胞。

The purpose of this project was to clarify the signal transduction of malassez epithelial rest. In the 1998, we reported that the mechanism of the fragmentation of Heltwiz epithelial root sheath and proliferation mechanism of epithelial rest of Malassez. In the 1999, we also reported that mesenchymal cell could migrate between the fragmented epithelial sheath and attach to the inner enamel epithelium, and the mesenchymal cell receives some signals from the inner enamel epithelium, and then they were differentiated to the cementoblast. In the 2000, the process that epithelial rest of Malassez was left in the cement was studied.With the advance of the formation of tooth root, the basement membrane of some epithelial cluster regenerate, and they are left in the periodontal ligament as Malasse'z epithelial rest. On the other hands, regeneration of the basement membrane is retarded on the result of contacting the mesenchymal cell, they are embedded in the cement by the substrate deposition of the cementoblast. The cell death is caused, when the regeneration of basement membrane is not carried out, and the cementum substrate has enclosed it.It is indicated that the message from Malassez epithelial rest is important in order to desire the periodontium, especially the regeneration of the cementum, clinically lost. By giving the signal from the epithelium in the remainder periodontium, the differentiation of the periodontal ligament to the cementoblast happens.