Role of oxidative stress and prevention by food factors in diabetes complications

氧化应激可能会引起自由基反应，在膜、蛋白质、酶和DNA中产生有害的修饰。我们已经开发了许多类型的针对氧化损伤的脂质和蛋白质的单抗，特别是针对。己酮基赖氨酸结构，由亚油酸过氧化氢与赖氨酸反应而产生，也是中性粒细胞氧化损伤蛋白质所产生的二羟甲基赖氨酸所特有的。使用这些单抗，我们检测了秋田小鼠的早期氧化应激，即2型糖尿病模型小鼠。我们还成功地研究了姜黄素(姜黄素)对高糖饮食大鼠氧化应激和糖尿病发病的保护作用。姜黄素长期以来被广泛用于治疗扭伤和炎症，四氢姜黄素(THC)和四氢姜黄素(THC)被发现是姜黄素在肠道吸收过程中产生的，比姜黄素具有更强的抗氧化性。通过详细的实验，我们发现THC对糖尿病并发症的预防作用比姜黄素强得多，并对具体的反应机理进行了讨论。

Oxidative stress may cause free radical reactions to produce deleterious modifications in membranes, proteins, enzymes and DNA.We have developed many types of monoclonal antibodies, which are specific to oxidatively damaged lipids and proteins, especially, monoclonal antibodies specific to. hexanonyl lysine structure which is caused by the reaction linoleic acid hydroperoxide with lysine and also specific to dityrosine caused from oxidatively damaged protein by neutraphil. Using these monoclonal antibodies, we detected oxidative stress at the early stage in Akita mouse, type 2 diabetes model mouse. We also succeeded in protective role of curcumins, main yellow pigments of Curcuma longa (turmeric) in oxidative stress and diabetes catract in high-suger fed rats. Curcumin has been used widely and for a long time in the treatment of sprain and inflammation in indigenous medicine and tetrahydrocurcumin (THC) and THC was found to be produced from curcumin during absorption from the intestines, and more potent antioxidant than curcumin. By the detailed experiments, we found that THC prevents the diabetes complications much stronger than curcumin, and detailed reaction mechanisms are discussed.