Relationship between life-style and cause of death in Higashi-Yamanashi cohort

背景：自1989年以来，我们在日本东山梨县的三个市进行了一项队列研究。这项研究的参与者是大约9000名年龄在30岁以上的人。我们在1989年进行了一项调查，采用自填问卷，包括约200项基线生活方式。目的：本研究的目的是评估日本Higashi-Yamanashi队列中与生活方式相关的危险因素，特别是食物摄入对脑梗死、胃癌和肺癌死亡率的影响。方法：收集1989 ~ 1999年的生命统计资料和死亡证明，并与基线资料相联系。结果:表1存活人数死亡和迁出病例（1989 ~ 1999年）男性（%）女性（%）存活3438例（80.2例）4111例（86.0例）死亡676例（15.8例）464例（9.7例）迁出175例（4.1例）204例（4.3例）总数4289例（100.0例）4779例（100.0例）表2死亡原因死亡原因数量（%）恶性肿瘤374例（33.2例）胃癌91例（8.0例）肺癌64例（5.6例）心脏病…More 202例（17.7例）脑血管疾病149例（13.1例）脑梗死93例（8.2例）其他415例（36.4例）总数1140例（100.0）表3几种危险因素的危险比梗死-男性风险比（95%CI）饮酒（ex/non） 2.3（1.1-1.5）每天睡眠时间（9+/7-8）2.0（1.1-3.8）奶酪摄入量（1-2 / m/non） 0.3（0.3-0.9）日本蛋糕（1-2 / m/non） 0.1（0.0-0.7）脑梗死-女性风险比（95%CI）每周运动（1小时+/non） 2.0（1.0-4.3）咸菜摄入量（每天/非）0.3（0.1-0.9）胃癌男性风险比（95%CI）每周鱼摄入量（3-4/<1-2）2.8（1.1-7.3）每周运动（5小时+/non） 2.4（1.1-5.3）每天步行时间（0.5小时+/non） 0.4（0.2-0.8）绿色蔬菜摄入量（1+ / M/non） 0.2（0.1-0.95）胃癌-女性风险比（95%CI）番茄摄入量（1-2 / w/non）0.2（0.1-0.8）肺癌（男性）风险比（95%CI）海藻摄入量（每天/non） 0.3（0.1-0.9）结论：绿色蔬菜摄入和步行可能是胃癌的预防因素。然而，进一步的分析将是必要的。少

Background : In the three municipalities of Higashi-Yamanashi County, Japan, we conducted a cohort study since 1989.Participants of this study were about 9,000 persons aged over 30 years. We conducted a survey using self-administered questionnaires consisted of about 200 items of baseline life-style on 1989.Purpose : The aim of this study was to evaluate the effect of life-style related risk factors, especially food intake, for mortality of cerebral infarction, stomach cancer, and lung cancer in the Higashi-Yamanashi cohort in Japan. Methods : Vital statistics and death certificates were obtained from 1989 to 1999 and linked with the base-line data. Results : Table. 1 Number of survival, death and move out cases(1989〜1999) Male(%) FeMale(%) Survive 3438(80.2) 4111(86.0) Death 676(15.8) 464(9.7) Move out 175(4.1) 204(4.3) Total 4289(100.0) 4779(100.0) Table. 2 Causes of death Cause of death Number(%) Malignant neoplasms 374(33.2) Stomach cancer 91(8.0) Lung cancer 64(5.6) Heart diseases … More 202(17.7) Cerebrovascular diseases 149(13.1) Cerebral Infarction 93(8.2) Others 415(36.4) Total 1140(100.0) Table. 3 Hazard risk ratio of several risk factors Cerebral infarction-Male Hazard Ratio(95%CI) Alcohol drinking(ex/non) 2.3(1.1-1.5) Sleeping hours per day(9+/7-8) 2.0(1.1-3.8) Cheese intake (1-2per m/non) 0.3(0.3-0.9) Japanese cake(1-2 per m/non) 0.1(0.0-0.7) Cerebral infarction-Female Hazard Ratio(95%CI) Exercise per week(1h+/non) 2.0(1.0-4.3) Pickles intake(everyday/non) 0.3(0.1-0.9) Stomach Cancer-Male Hazard Ratio(95%CI) Fish intake per week(3-4/<1-2) 2.8(1.1-7.3) Exercise per week(5h+/non) 2.4(1.1-5.3) Walking time per day(0.5h+/non) 0.4(0.2-0.8) Green vegetable intake(1+ per M/non) 0.2(0.1-0.95) Stomach Cancer - Female Hazard Ratio(95%CI) Tomato intake(1-2 per w/non)0.2(0.1-0.8) Lung Cancer(Male) Hazard Ratio(95%CI) Seaweed intake(everyday/non) 0.3(0.1-0.9) Conclusions : Green vegetable intake and walking may be preventive factors for stomach cancer. However, further analysis will be necessary. Less