Antitumor activity by intracellular hyperthermia using magnetite

本实验观察了高温条件下新制备的羧甲基纤维素（CMC）-磁铁矿的瘤内效应。将CMC与磁铁矿颗粒混合，制成棒状磁铁矿，以获得较高的热效应。将该磁铁矿立体定向注射到大鼠脑内T9胶质瘤中，并将这些大鼠施加到高频磁场中。棒状CMC-磁铁矿在施加到磁场中后在肿瘤组织中扩散。这种静磁场的应用也刺激了磁铁矿颗粒，并可能产生足以诱导肿瘤坏死的热量。这项高温研究还表明，在磁铁矿周围聚集了巨噬细胞和淋巴细胞，这表明加热磁铁矿可能诱导脑中免疫反应的激活

Intratumoral effect of Carboxymethylcellulose(CMC)-magnetite, which newly produced, under hyperthermic condition was demonstrated in this study. CMC and magnetite particles were mingled and a stick type magnetite was developed to obtain higher hyperthermic effect. This type magnetite was injected stereotactically into the T9 glioma in the rat brain and these rats were applied to the high frequent magnetic field. Stick type CMC-magnetite spread among the tumor tissue after application into the magnetic field. This static magnetic field application also stimulates the magnetite particles and could produce heat enough to induce tumor necrosis. This study of hyperthermia also demonstrated assembling macrophages and lymphocytes just around the magnetite, which indicates possibility of heated magnetite to induce activation of immunoreaction in the brain