Neurotranplantation and deep brain electrical stimulation for Parkinson's disease

在本研究项目中，我们研究了自体交感神经节脑内移植对帕金森症状的影响。我们还对帕金森病患者进行了苍白球脑深部电刺激的临床研究，接受交感神经节移植的患者中有50%的患者步态障碍和运动迟缓等帕金森病症状得到改善。然而，移植后患者的肌肉僵硬和震颤并没有改善。这些影响持续到移植后6年。对20名帕金森病患者进行了苍白球的时序电刺激。约60%的患者表现出帕金森症状的改善，特别是药物引起的运动障碍、肌肉僵硬和运动迟缓。电刺激苍白球1小时后，脑室液中GABA含量升高，神经递质如GABA、多巴胺等儿茶酚胺类物质被检测。这些研究清楚地证明了移植和脑深部刺激对帕金森病患者症状的影响。

In the present research project we have investigated effect of transplantation of autologous sympathetic ganglion into the brain on parkinsonian symptoms. We also studied clinical research for deep brain stimulation of the globus pallidus in Parkinson patients.Fifty percent of the patients receiving transplantation of sympathetic ganglion showed improvement of parkinsonian symptoms such as gait disturbance and bradykinesia. However, the patients did not show improvement of muscle rigidity and tremor after transplantation. These effects continued up to 6 years after transplantation.Chronic electrical stimulation of the globus pallidus was performed in 20 patients with Parkinson disease. About 60% of the patients showed improvement of Parkinson symptoms, especially drug-induced dyskinesia, muscle rigidity and bradykinesia. Neurotransmitters such as GABA, dopamine and other catecholamines were measured during electrical stimulation of the globus pallidus, which showed elevation of GABA in the ventricular fluid 1hr after stimulation.These studies clearly demonstrated the effects of transplantation and deep brain stimulation on symptoms in patients with Parkinson disease.