Transplantation of Neural Tissue into Parkinsonian Brain

将神经组织移植到帕金森病大脑中

• 批准号: 06671414
• 负责人: ITAKURA Toru
• 金额: $ 1.02万
• 依托单位: Wakayama Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671414/
• 关键词: Parkinson's disease; neural transplantation; neurotrophic foctor; interleukin; 交感神経節; インターロイキン; 6-OHDA; 組織培養

We have investigated the effect of transplantation of the sympathetic ganglion cells into parkinsonian patients. Based on encouraging data obtained from experimental studies, we have clinically applied this technique for parkinsonian patients. Tow thirds of the patients revealed effects of transplantation of the sympathetic ganglion. However, one thirds of the patients did not show any effects of transplantation. In this projects, we demonstrated effect of pretreatment of nerve trophic factors on survival of transplanted cells in the host brain. Nerve growth factor and interleukin-1 enhanced survival of the graft and behavioral effects after transplantation. In clinical study, we demonstrated important factors influencing prognosis of parkinsonian patients receiving transplantation. The patients showing long duration of the symptoms and many Lewy bodies in the ganglion resulted in poor prognosis after transplantation.These results indicate that transplantation of sympathetic ganglion cells into the brain becomes a new therapeutic modality of Parkinson's disease.

我们研究了交感神经节细胞移植到帕金森病患者的效果。基于从实验研究中获得的令人鼓舞的数据，我们已经在临床上将这种技术应用于帕金森病患者。三分之二的患者显示交感神经节移植的效果。然而，三分之一的患者没有表现出任何移植效果。在这个项目中，我们证明了神经营养因子预处理对移植细胞在宿主脑中存活的影响。神经生长因子和白细胞介素-1增强移植物的存活和移植后的行为效应。在临床研究中，我们展示了影响帕金森病患者接受移植的预后的重要因素。结果提示，交感神经节细胞脑内移植治疗帕金森病，可为临床提供一种新的治疗手段。

项目成果

Nakao N.Itakura T et al.: "Transplantation of cultured synpathetic ganglionic neurons into parkinsonian rat brain" Acta Neurochir. 133. 61-67 (1995)

Nakao N.Itakura T 等人：“将培养的交感神经节神经元移植到帕金森病大鼠大脑中”Acta Neurochir。

板倉徹 他: "頚部交感神経節の脳内移植" 脳神経外科. 22. 199-205 (1994)

Toru Itakura 等人：“颈交感神经节的脑内移植”《神经外科》22. 199-205 (1994)。

Itakura T.,Komai N.,et al.: "Autelogous transplantation of the cervical sympathetic ganglion into the parkinsonian brain:case report" Neurosurgery. 35. 155-158 (1994)

Itakura T.，Komai N.，等人：“颈交感神经节自体移植到帕金森病大脑中：病例报告”神经外科。

板倉徹 他: "神経科学の基礎と臨床「視床下部」" ブレーン出版, 171 (1995)

Toru Itakura 等人：“基础和临床神经科学‘下丘脑’”Brain Publishing，171 (1995)

Nakao N.Itakura T et al.: "Pretreatment with interleukin‐1 enbances Survival of Sympathetic ganglionic neuron grafts" Neurol Med Chir. 34. 407-411 (1994)

Nakao N.Itakura T 等人：“用白细胞介素 1 进行预处理可促进交感神经节神经元移植物的存活”Neurol Med Chir. 34. 407-411 (1994)