Transplantation of cervical sympathetic ganglion into the brain with Parkinson's disease

将颈交感神经节移植到患有帕金森病的大脑中

• 批准号: 08457372
• 负责人: ITAKURA Toru
• 金额: $ 2.5万
• 依托单位: Wakayama Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457372/
• 关键词: Parkinson's disease; neural transplantation; free radical; sympathetic ganglion; free radical

We have investigated the effect of transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease. Base on encouraging data obtained from experimental studies, we have clincally applied this new therapeutic modality for 50 patients with Parkinson's disease. In this project we have demonstrated that free radical interfered the survival of the graft and free radical inhibitor enhanced survival rate and functional recovery of transplanted animals. In the clinical study, we have revealed that half the patients showed amelioration of gait and movement in the patients for 5-6 years after transplantation. In contrast, the rest of half patients did not show improvement of the symptoms even after the transplantation. Influencing factors for outcome of the patients were duration of the disease and severity of symptoms. The present stud suggests that administration of free radical inhibitors may enhance the effects of sympathetic ganglion of parkinsonian symptoms.

我们研究了自体交感神经节移植到帕金森病脑内的效果。基于从实验研究中获得的令人鼓舞的数据，我们已经将这种新的治疗方式应用于50名帕金森病患者的临床治疗。在这个项目中，我们证明了自由基干扰移植物的存活，自由基抑制剂提高了移植动物的存活率和功能恢复。在临床研究中，我们发现有一半的患者在移植后5-6年的时间里步态和运动都有改善。相比之下，其余一半患者即使在移植后也没有表现出症状的改善。影响患者预后的因素有病程和症状严重程度。本研究提示，使用自由基抑制剂可增强交感神经节对帕金森症状的影响。

项目成果

上松 右二, 湯川 修也 大岩 美嗣, 板倉 徹: "神経移植における神経伝達物質とその受容体" Medical View, (1996)

Yoshiji Agematsu、Shuya Yukawa、Yoshitsugu Oiwa、Toru Itakura：“神经移植中的神经递质及其受体”医学观点，（1996）

上松右二,湯川修也,大岩美嗣,板倉 徹: "神経移植における神経伝達物質とその受容体" Medical View, (1996)

Yoshiji Agematsu、Shuya Yukawa、Yoshitsugu Oiwa、Toru Itakura：“神经移植中的神经递质及其受体”医学观点，（1996）

Itakura T, Uematsu U Nakao N, Nakai E, Nakai K: "Transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease.Long-tern follow-up of 35 cases." 11th International Congress of Neurological Surgery. 2025-2029 (1997)

Itakura T、Uematsu U Nakao N、Nakai E、Nakai K：“将自体交感神经节移植到患有帕金森病的大脑中。对 35 例病例进行长期随访。”

ITAKURA T,et al.: "Stereotactic surgery and endovascular surgery" Rehabilitation Med. 33. 602-605 (1996)

ITAKURA T 等人：“立体定向手术和血管内手术”康复医学。

Emgard-Mattson M: "Addition of lateral ganglionic eminence to rat mesencephalic grafts affects fiber outgrowth but does not enhance function." Cell Transplant. 6. 277-286 (1997)

Emgard-Mattson M：“在大鼠中脑移植物中添加外侧神经节隆起会影响纤维生长，但不会增强功能。”