Search for Indonesian Marine Life as Medicinal Resource (2)

海洋将继续对人类的未来发挥重要作用，不仅是食物和能源的来源，而且对环境的保护。除了这些作用，海洋还有望提供生物活性物质，这些物质有可能被开发成新药。由于工业和城市污水以及土地开发所排放的红粘土的沉积造成的沿海环境恶化，日本海岸的无根海洋生物的生存受到威胁。印度尼西亚也出现了类似的情况，特别是雅加达和其他沿海城市的沿海地区。考虑到这些情况，重要的是在印度尼西亚海洋生物从沿海水域消失之前，开始研究这些生物作为新药先导化合物的来源。目前的研究是由该项目与印度尼西亚的海洋研究与发展中心、大阪大学和日本琉球大学合作进行的。这项建议的目标是对印度尼西亚海洋生物的药用潜力进行联合研究，并促进印度尼西亚和日本在海洋生物学、天然产物化学和生物医学科学等学科方面的科学交流。众所周知，印度尼西亚水域富含海绵和软珊瑚等各种各样的无根生物。然而，人们对它们的区域和生物分布以及生物医学潜力知之甚少。我们是一组来自印度尼西亚和日本的科学家，旨在对这些生物进行调查、收集和化学和药物研究。1999年8月在北苏拉威西的比东珊瑚礁，2000年8月在南苏拉威西的肯达里珊瑚礁，2001年8月在弗洛雷斯岛的拉万巴霍珊瑚礁进行了调查。采用水肺潜水法对海绵、被囊动物等无脊椎动物进行了调查和采集。采集样品的提取物进行筛选生物实验（抗菌活性、对培养肿瘤细胞（KB、L1210）的细胞毒活性、肿瘤细胞（KV-C2、KV-CV60、KB-3-1细胞系）的多药耐药逆转活性及其他病毒学活性）。少

The sea will continue to play important roles for the future of human being not only as the source of food and energy but also for the conservation of environment. Other than these roles, the sea is also expected to provide biologically active substances, which have potential to be developed into new medicines. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakkarta and other coastal cities. Considering these situations, it is important to initiate the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters.The present research is carried out by the project in collaboration with Pusat Penelitian dan Pengembangan Oseanologi (Res … More earch and Development Center for Oceanology)- LIPI, Indonesia and Osaka University and University of the Ryukyus, Japan. The objectives of this proposal are to conduct a joint research on medicinal potential of Indonesian marine organisms and to promote scientific exchange between Indonesia and Japan in the disciplines encompassing marine biology, natural product chemistry, and biomedical science. The Indonesian waters are known to be rich in diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential are scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conduct survey, collection, and chemical and pharmaceutical investigation of these organisms.The survey was proceeded at the coral reef of bitung, North Sulawesi, in August, 1999, the coral reef Kendari, South Sulawesi in August, 2000, and the coral reef of Labuanbajo, Flores Island in August, 2001. Mainly sessile invertebrates such as sponges and tunicate were surveyed and collected by scuba diving. The extracts of collecting samples were subjected to the screening bioassays (e. g. antimicrobial activity, cytotoxic activity against cultured tumor cells (KB, L1210), reversal activity of multi-drug resistance in tumor cell (KV-C2, KV-CV60, and KB-3-1 cell lines), and other viological activities. Less