Study of Automatic Information Processing of Background Sound and Speech in Schizophrenic Patients with auditory Hallucination

事件相关脑电位（ERPs）中的失配负性（MMN）分量反映了与自动信息加工相关的记忆过程。另一方面，一些研究表明，精神分裂症患者的认知功能缺陷也反映在MMN的生成受损上。我们通过时间整合窗口（TWI）（2001,2002,2004）报道了感觉记忆内部的自动判别灵敏度作为时间的函数（2005）。我们还报道了听觉流和时间整合的相互作用，在大脑中组织声音序列（2001,2003），进化听觉信息整合的光谱时间窗口（2003）。我们发现瞬态伽玛带反应应该与感觉记忆分离，正如MMN所反映的那样。我们通过使用体感范式（2002）显示了早期偶然负性变异（CNV）的一个小的对称负性。此外，我们的CNV研究揭示了精神分裂症患者额叶注意转换机制的激活受损（2004）。我们报道了hiba气味对CNV和MMN的不同影响（2002,2001）。我们发现在精神分裂症的急性期和后急性期之间的错配消极性的差异（2002年，2002年）。通过研究语音中的MMN，我们发现了语音感知后向掩蔽效应的皮层证据（2003）。在国际听觉记忆会议（MMN2000，巴塞罗那）的研讨会上，我们提出了听觉记忆在精神分裂症中的整合功能。

Mismatch negativity (MMN) component of the event-related brain potentials (ERPs) reflects the memory process related to the automatic information processing. On the other hand, several studies indicated that deficits of cognitive function in schizophrenia were also reflected in the impaired generation of MMN. We reported the automatic discriminative sensitivity inside the sensory memory as reflected by Temporal Window of Integration (TWI) (2001,2002,2004), as a function of time (2005). We also reported the interplay of auditory streaming and temporal integration, organizing sound sequences in the brain (2001,2003), evolving the spectrotemporal window of integration of auditory information (2003). We found that the transient gamma-band response should be dissociated from sensory memory as reflected by MMN (in press). We showed a small symmetrical negativity of the early contingent negative variation (CNV) by using a somatosensory paradigm (2002). Also, our CNV study revealed the impairment in activation of a frontal attention-switch mechanism in schizophrenic patients (2004). We reported the differential effects of the hiba odor on CNV and MMN (2002,2001). We found the difference in mismatch negativity between the acute and post-acute phase of schizophrenia (2002,2002). By studying MMN in speech, we showed the cortical evidence of the perceptual backward masking effect on speech sounds (2003). In the symposium of the international MMN conference (MMN2000, Barcerona), we presented the integrative functions of auditory sensory memory in schizophrenia.