An evaluation of cognitive impairment related to cerebellar degeneration ; A study using event-related potentials

最近的研究表明，小脑参与认知功能。目前尚不清楚脊髓小脑变性患者是否有认知功能障碍或仅继发于运动功能障碍的认知缺陷。本研究的目的是通过测量事件相关电位（ERP）和神经心理学测试来评估皮质性小脑萎缩（CCA）患者的认知功能障碍。此外，为了避免运动受累，还分析了脑电图和中潜伏期听觉反应（MLRs）。对于ERP记录，我们使用了连续表现任务，该任务评估了注意力表现和控制运动反应的能力。使用20个头皮电极记录脑电活动，并计算成一系列电位分布图。利用低分辨率脑电断层扫描（LORETA）计算脑内电活动的三维分布。神经心理学测试也进行了评估。在无围棋条件下，CCA患者的GFP峰潜伏期延长，GFP峰潜伏期减弱，但两组在听觉怪球任务和围棋条件下无差异。与对照组相比，LORETA显示No Go P3期CCA患者额叶源激活较低。用经典方法分析脑电和多导磁共振也没有发现任何差异。LORETA分析显示，以Brodmann区45为中心的左额下丘脑α 2活性明显降低。在MLRs上，P1部分差异最显著，CCA患者在以Brodmann区9为中心的右侧额上回明显下降。我们的研究结果表明，CCA患者的额叶特别是抑制系统和上行网状激活系统受到抑制，表明小脑参与认知功能，而不考虑运动辅助。少

Recent studies have indicated the involvement of the cerebellum in cognitive function. It is not clear whether patients with spinocerebellar degeneration have cognitive dysfunctions or only cognitive deficits secondary to motor dysfunction. The aim of the study was to evaluate the profile of cognitive impairment in patients with cortical cerebellar atrophy (CCA) by measurement of event-related potentials (ERP) and neuropsychological tests. In addition, to avoid motor involvement, EEG and the midlatency auditory responses (MLRs) were also analyzed. For ERP recording, we used the continuous performance task, which evaluates the attentional performance and ability to control a motor response. Brain electric activity was recorded using 20 scalp electrodes and computed into series of potential distribution maps. The global field power (GFP) were determined, and low-resolution brain electromagnetic tomography (LORETA) was used to compute the three-dimensional intracerebral distribution of el … More ectric activity of the records. A neuropsychological test battery was also assessed. GFP peak latency was prolonged and GFP peak was attenuated under the No Go condition in patients with CCA, although there were no differences in the auditory oddball task and in the Go condition between the two groups. LORETA showed low activation of frontal source in CCA patients in No Go P3 compared with the controls. Analysis of EEG and MLRs using classical methods also did not reveal any differences. LORETA analysis indicated significant decrease of alpha2 activity in the left inferior frontal gyms centering around Brodmann area 45 in CCA. On MLRs, the most significant difference was observed at P1 component, and CCA patients showed significant decrease at the right superior frontal gyrus centering around Brodmann area 9. Our results suggest that the frontal lobe especially inhibitory system and ascending reticular activating system are inhibited in CCA patients, and indic ate the involvement of the cerebellum in cognitive function irrespective of motor adjunct. Less