Development of an interferometric nanoscale silicon biosensor

Voelcker等人最近证明了多孔硅被某些超分子过渡金属络合物（称为金属蛋白的功能模拟物）快速降解。催化降解形成了一种新的传感器原理的基础，其中多孔层用作基质、换能器和信号放大级。该项目使用多孔硅降解来开发能够以高灵敏度检测一系列分析物的生物传感器平台。该项目包括检测一种水媒毒素、一种植物病毒和一种癌抗原，以证明其广泛适用性。还包括多路复用的生物传感器，以证明其作为高通量芯片传感器的潜力。

Voelcker et al. have recently demonstrated the rapid degradation of porous silicon by certain supramolecular transition metal complexes known as functional mimics of metalloproteins. The catalyzed degradation forms the basis of a new sensor principle where the porous layer serves as matrix, transducer and signal amplification stage. This project uses porous silicon degradation to develop a biosensor platform capable of detecting a range of analytes with high sensitivity. The project includes detection of an water-borne toxin, a plant virus and a cancer antigen as demonstrators of its wide applicability. Multiplexing of the biosensor to demonstrate its potential as high-throughput chip sensors is also included.