Cell cycle and enteric neuron and glial differentiation

肠神经元起源于一个非常小的前体（神经嵴）细胞的起始群体，其中大部分从后脑迁移，并殖民发展肠道。 经过一段长时间的前体增殖和分化成神经胶质和许多不同类型的神经元。 细胞周期退出是许多神经元类型发育中的关键事件，主要是因为细胞退出细胞周期的时间限制了将产生的神经元的数量。 我们将确定退出细胞周期是否有助于肠神经元和神经胶质的分化和规范。

Enteric neurons arise from a very small starting population of precursor (neural crest) cells, most of which emigrate from the hindbrain, and colonise the developing gut. Over a protracted period of time the precursors proliferate and differentiate into glia and many different types of neurons. Cell cycle exit is a critical event in the development of many neuron types, largely because the time at which cells exit from the cell cycle limits the number of neurons that will be generated. We will determine whether exit from the cell cycle contributes to the differentiation and specification of enteric neurons and glia.