Establishment of diagnostic and treatment strategies for chronic fatigue syndrome

从2004年至2006年，我们进行了以下研究，以探索慢性疲劳综合征（CFS）的未知机制，并寻找客观评估的工具。对象：60例以全身疲劳为主诉的患者。临床信息、实验室数据，包括血清激素和抗人类疱疹病毒抗体（HHV 6和7）或贝氏柯克斯体（Coxiella burnetti），以及外周血细胞中应激反应基因的mRNA表达。1）4例患者血清中HHV 6、HHV 7滴度升高，但与CFS无关; 2）无一例患者血清中抗伯氏柯克斯体抗体升高; 3）将临床上以疲劳为主诉的患者分为CFS、精神疾病、器质性疾病和病因不明4组。26例CFS患者中，CFS 8例，精神疾病11例，器质性疾病4例，病因不明3例。4）确定了9个可能用于检测CFS患者病理反应和鉴别诊断的基因。

We performed the following investigations to explore unknown mechanism underling the chronic fatigue syndrome (CFS) syndrome and to find tools for objective assessment from 2004 to 2006.SUBJECTS : Sixty patients with the chief complaint of general fatigueMEASUREMENTS: Clinical information, laboratory data including serum hormones and antibodies against human herpes viruses (HHV 6 and 7) or Coxiella burnetti, and mRNA expression of stress-responsive genes in peripheral blood cells.MPARTICIPTED CLINICIANS: All patients were clinical assessed by general internists as well as psychiatrist.TREATMENTS: All patients were treated by traditional herbal medicine according to the patients clinical conditions ‘Sho'.RESULTS:1) Increased HHV6 and HHV7 titers were noted in 4 patients, but they were not particularly related with CFS.2) No patient showed the increased antibodies against Coxiella burnetti.3) Clinically patients with the chief complaint of general fatigue were divided into 4 groups: CFS, psychiatric disease, organic disease, and undetermined etiology. Amongst 26 patients who were fully investigated CFS 8 cases, psychiatric disease 11 cases, organic disease 4 cases, and undetermined etiology 3 cases.4) Nine genes that may be useful for detection of pathological responses in CFS patients and for differential diagnosis of this syndrome were determined.5) ‘Sho' did not shoe any particular pattern.