Construction of a system to assess and improve cognitive impairment in elderly people with dementia

本研究的目的是证明我们设计的自行车测力计速度反馈治疗系统对老年痴呆症患者认知功能的有效性，并阐明该系统是否可以改善认知功能，以及额叶皮层的神经激活在改善认知功能中的作用。结果表明：（1）干预组干预前、干预后即刻、干预后1个月简易精神状态检查量表、老年人N型日常生活活动能力评定量表、老年痴呆患者生活质量评定量表评分变化与对照组比较均有显著性差异。此外，完成干预后立即注意力得分显着高于干预前。(2)在40%运动时测量O2 Hb时，发现O2 Hb在运动后逐渐持续增加，持续时间超过5分钟，表明中等强度的动态运动改善认知功能。(3)Stroop色词测验（SCWT）中O_2Hb逐渐升高，在SCWT开始后40- 50 s达高峰，运动前后SCWT中O_2Hb的相对升高幅度相同，提示额叶脑氧代谢的改变可能与认知功能的改善有关。

The purpose of this study was to demonstrate the efficacy in terms of the cognitive function of elderly people with dementia of a speed-feedback therapy system with a bicycle ergometer we devised, and to clarify whether the system could improve cognitive function, and neural activation in the frontal cortex played a role in improving cognitive function. The results were as follows:(1) The changes in scores on the Mini-Mental State Examination, N.type Activities of Daily Living Evaluation Scale for the Elderly, and QOL Scale for Elderly Persons with Dementia evaluation scales between before the intervention, immediately after the intervention, and 1 month after the intervention all showed significant differences between the intervention group and the control group. In addition, the attentiveness score immediately after completion of the intervention was significantly higher than before the intervention.(2) When measuring O2Hb during 40% exercise, a gradual and sustained increase in O2Hb was found, which lasted for more than 5 minutes following exercise, suggesting that dynamic exercise with a moderate intensity improve cognitive function.(3) O2Hb gradually increased in the Stroop color-word test (SCWT) and peaked 40-50s after SCWT onset, and its relative increase of O2Hb by SCWT was the same before and after exercise, suggesting that The changes of cerebral oxygen metabolism in the frontal cortex may be in association with improved cognitive function.