Target-tracking system in the stereotactic radiation therapy for body tumors

(1)利用多排螺旋CT成功地进行了肺癌的四维成像。（2）利用平板探测器进行MV X线透视，实现了实时肿瘤成像。(3)利用放射治疗机研制了千伏级X射线CT成像技术。(4)呼吸曲线是从通过千伏X射线成像获得的患者隔膜位置推导出来的。(5)一种治疗kV锥束CT成像技术已经建立。(6)已经开发了一种用于测量患者摆位误差的方法，用于治疗前即刻、治疗期间和治疗后即刻的立体定向放射治疗。临床研究也已启动。(7)一个实时的肿瘤跟踪系统已经开发通过检测肿瘤的位置估计从患者的横膈膜位置使用治疗kV的X射线成像。(8)至于大口径CT在放射治疗中的临床应用。我们已将90 cm口径CT应用于放射治疗实践。(9)通过增加MW最大叶片速度，开发了一种肿瘤跟踪算法。(10)调强弧治疗已成功地控制剂量率和机架速度。(11)我们已经解决了一个问题，并提出了一个解决方案，将以前开发的X波段直线加速器应用于放射治疗实践。(12)从机器人工程的角度研究了利用机器人臂式直线加速器进行肿瘤实时跟踪。(13)我们已经设计了一个新一代的跟踪系统相结合的直线加速器与机器人手臂和CT成像仪。(14)通过使用内置CT成像单元，在治疗前即刻、治疗期间和治疗后即刻定位靶器官和风险器官。(15)我们已经发现市售药物具有放射增敏作用，并揭示了其放射生物学机制。(16)总体评价和临床应用我们将研究结果应用于临床实践，取得了显著的治疗效果。

(1) Four-dimensional lung cancer imaging has been successfully performed by using a multi-detector CT(2) Real-time fluoroscopic tumor imaging has been achieved by using a flat panel detector for MV x-ray.(3) A kilovolt x-ray CT imaging technique has been developed by using radiotherapy machine.(4) A respiratory curve has been derived from the patient diaphragm position obtained by kilovoltage x-ray imaging.(5) A technique for in-treatment kV cone beam CT imaging has been established.(6) A method for measuring patient set-up errors has been developed for stereotactic radiotherapy immediately before treatment, during treatment, and immediately after treatment. Clinical study has also been launched.(7) A real-time tumor tracking system has been developed by detecting the tumor position estimated from the patient diaphragm position using in-treatment kV x-ray imaging.(8) As for clinical application of large bore CT for radiotherapy. We have applied a 90 cm bore CT to radiotherapy practice.(9) A tumor tracking algorithm has been developed by increasing MW maximum leaf speed.(10) Intensity modulated arc therapy has been achieved by successfully controlling dose rate and gantry speed.(11) We have addressed a problem and proposed a solution to apply previously developed x-band linac to radiotherapy practice.(12) Real-time tumor tracking using robot arm-mounted linac has been studied from a robot engineering view.(13) We have designed a next-generation tracking system by combining a linac with a robot arm and a CT imager.(14) The target and risk organs have been localized immediately before treatment, during treatment and immediately after treatment by using built-in CT imaging unit.(15) We have discovered that commercially available drug serves as a radiosensitizer, and have revealed its radiobiological mechanism.(16) Total assessment and clinical application We have obtained significant treatment outcome by applying our results to clinical practice.