The development of the prophylactic by the vaccine for stomatitis caused by Candida induced by the use of denture in elderlies who need care

为建立口腔无症状携带者模型，对未经治疗的兔口服接种少量白色念珠菌。每日口腔拭子样本中白色念珠菌的菌落形成单位增加，并在一周内保持在较高水平，口腔粘膜上未出现白色斑块。虽然薄片上可见真菌丝存在于口腔粘膜角化层内，但在周围组织中未见炎性细胞的聚集。抗C。当拭子标本中白念珠菌平均菌落数大于500CFU时，部分兔血清中可诱导出白念珠菌Ig G作为感染标志，而抗体对低于150CFU者则不能诱导。我们提出了白念珠菌从口腔携带者向感染转化的细胞密度依赖模型假说。

To obtain a model of asymptomatic oral carriers, non-treated rabbits were orally inoculated with small number of Candida albicans. Colony-forming units of C. albicans in daily oral swab samples increased and stayed at high levels in a week without causing white patches on oral mucosa. Although fungal filaments were found within the cornified layer of oral mucosa in thin sections, the accumulation of the inflammatory cells was not found in the surrounding tissues. Anti-C. albicans IgG as the sign of infection was induced in serum of some rabbits having greater than 500 CFU of the average C. albicans CFU in swab sample, but the antibodies did not induce those less than 150 CFU. We proposed the hypothesis of the cell density dependent model for the transition to the infection from oral carrier of C. albicans.