Interaction between genetic and environmental factors in metabolic syndrome

胰岛素抵抗、高血压和血脂异常的聚集性被标记为代谢综合征。亚洲人的肥胖率低于高加索人，但有增加代谢综合征的趋势。关于代谢综合征的研究大多基于西方国家的研究，仅从亚洲人群中获得有限的信息。为了研究β3肾上腺素能受体基因Trp64Arg多态和解偶联蛋白1基因(-3826A〓&Gt；G)多态与日本人体重减轻的独立效应和联合效应。从2000年到2005年，300名受试者(男性72名，年龄53.5±11.6岁，女性228名，年龄55.8±9.1岁)参加了为期3个月的社区教育干预试验。参与者有28%的超重(23.0-24.9BMI)和48%的肥胖(〓25BMD)。每个受试者均完成生活方式调整程序，体重减轻1.33±0.11 kg，能量平衡减少385±24.05千卡。The…用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测更多的β-3AR和UCP1基因多态性。一般线性模型(GLM-1)适用于检测体重变化与两个基因多态之间的关联。在控制了潜在的混杂变量后，携带Beta3AR基因突变的女性体重显著减轻，而男性则没有。(p=0.007)。无论男女，UCP1基因多态性对体重变化的影响均不显著。β3AR和UCP1基因多态性对体重变化的协同作用未发现有相加效应(p=0.167)。在超重和肥胖的日本人中，β3AR和UCP1基因多态性的协同作用可能是体重变化的一个微弱因素。我们还在工作场所对18-60岁的个人进行了横断面研究。根据国际糖尿病联合会(IDF)的定义，我们检查和分析了1,564名日本、中国和蒙古人的代谢综合征健康数据。按亚洲版腰围计算，日本人内脏肥胖症的患病率分别为10%和12%，中国人为39%和24%，蒙古族为51%和54%。代谢综合征的患病率日本人分别为7%和7%，中国人为24%和9%，蒙古族分别为22%和24%。日本人内脏肥胖症的发生率低于中国人和蒙古族人，但有增加肥胖相关代谢紊乱的趋势。随着社会经济的发展，亚洲劳动者中肥胖和代谢综合征的人数正在增加，但与肥胖相关的代谢紊乱在种族上存在显著差异。较少

A clustering of insulin resistance, hypertension and dyslipidemia has been labeled as metabolic syndrome. Asians have a lower frequency of obesity than do Caucasians, but have an increasing tendency toward metabolic syndrome. Most data on metabolic syndrome am based on studies from Western countries with only limited information derived from Asian populations.To investigate the independent and combined effects of the Trp64Arg polymorphism of the beta3-adrenergic receptor (beta3AR) gene and the (-3826) A〓>G polymorphism of the uncoupling protein 1 (UCP1) gene are associated with weight-loss of Japanese. 300 subjects (72 men of 53.5±11.6 years and 228 women of 55.8±9.1 years) participated in a community-setting educational interventional trials for three months from 2000 to 2005. Participants were 28% overweight (23.0-24.9 BMI) and 48% obese (〓25 BMD. Each subject was completed the life-style modification program, and reduced 1.33±0.11 kg of weight, 385±24.05 kcal of energy balance. The … More beta3AR and UCP1 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). General Linear Model (GLM-1) was fit to detect associations between body weight changes and the two gene polymorphisms. The body weight significantly reduced in women with beta3AR mutation but not in men, after controlling for potential confounding variables (p=0.007). The effect of UCP1 polymorphism on body weight change was not significant in both women and men. The synergistic effects of polymorphisms both beta3AR and UCP1 on body weight changes were not found to have additive effects (p=0.167). The synergistic effect of the beta3AR and the UCP1 gene polymorphism may be a weak contributing to body weight changes in Japanese with overweight and obese.We also conducted a cross-sectional study of individuals aged 18-60 yr in workplace settings We examined and analyzed the health data of 1,564 Japanese, Chinese and Mongolians for metabolic syndrome based on the International Diabetes Federation (IDF) definition. The prevalence of visceral obesity using the Asian edition of waist circumference was 10% and 12% for Japanese, 39% and 24% for Chinese, and 51% and 54% for Mongolians, respectively The prevalence of metabolic syndrome was 7% and 7% for Japanese, 24% and 9% for Chinese, and 22% and 24% for Mongolians respectively Japanese has a lower frequency of visceral obesity than do Chinese and Mongolians, but have an increasing tendency toward obesity-related metabolic disorders. Obesity and metabolic syndrome are increasing in Asian workers with their social-economical development, but obesity-related metabolic disorders are remarkably different relative to ethnicity. Less