Effects of vitamin B6 on children with autism : a randomized controlled trial

为了调查自闭症儿童维生素B6反应的预测因素，我们进行了一项干预研究，17名儿童参与了研究。他们都在干预前后完成了神经学和血液学检查。在前两周，维生素B6的剂量为5 mg/kg。在接下来的2周中，维生素B6的剂量为10 mg/kg。受试者中有3例被判定为“有效”。我们比较了“有效”组和“无效”组的特征和生物标志物。我们发现，同时具有“声音过敏”和“笨拙”或“低血浆谷氨酰胺浓度”的人预示着维生素B6的反应性。

To investigate the factors that predict vitamin B6 responsiveness in children with autism, we conducted an intervention study and 17 children have participated. They all completed the neurological and blood tests before and after the intervention. In the first 2 weeks, vitamin B6 was given in doses of 5mg/kg. In the following 2 weeks, vitamin B6 was given in doses of 10mg/kg. Among the participants, 3 cases were judged as "effective". We compared the characteristics and biomarkers between "effective" group and "ineffective" group. We found that simultaneously having "hypersensitivity to sound" and "clumsiness" or "low plasma concentration of glutamine" predicted the vitamin B6 responsiveness.