Effects of Notch Signaling on the Pulpal Cell Differentiation and the Horizon of Pulpal Regeneration by Regulation of Notch Signaling

成牙细胞分化过程涉及多种因素。我们揭示了Notch信号通路在成骨细胞分化中的重要性，提示Notch信号通路可能是调控间充质间质细胞向硬组织形成细胞分化的重要因素之一。在牙髓细胞中，Notch信号通路在成牙髓细胞分化过程中起着核心作用，活性Notch信号通路诱导的牙髓细胞仍未分化。Hey1是成骨/成牙细胞分化过程中Notch信号通路的主要转录因子，髓细胞中Hey1的强制表达会干扰成牙细胞的分化。

A numerous factors are involved in the course of odontoblastic differentiation. We revealed the importance of Notch signaling in the osteoblastic differentiation, suggesting that the Notch signaling may one of the essential factors to regulate the differentiation of mesenchymal stromal cells into hard tissue forming cells. In the pulp cells, Notch signaling took a central role of odontoblastic differentiation, and active Notch signaling induced pulp cells remained undifferentiated. Hey1 was a major transcriptional factor in the Notch signaling in the osteo/odonto-blastic differentiation, and enforced expression of Hey1 in the pulp cells were disturbed their odontoblastic differentiation.