Relationship between mechanism of the reduction of the nasal polyp by the indomethacin and the laminin

鼻息肉组织中层粘连蛋白α1、β1、Gamma1和Gamma2亚单位的免疫反应和mRNA表达均显著高于正常鼻窦黏膜。层粘连蛋白Gamma1亚单位表达的定位主要与基底膜增厚相一致。提示层粘连蛋白，尤其是层粘连蛋白的γ1亚单位在鼻息肉中的表达上调可能是鼻息肉发生发展的重要原因之一。然而，我们不能确定消炎痛减少鼻息肉的机制。

Both the immunoreactivity and mRNA of alpha1, beta1, gamma1, and gamma2 subunit of laminin were significantly detected in the nasal polyps in comparison with control normal sinus mucosa. The localization of gamma1 subunit of laminin expression predominantly coincided with thickened basement membrane. These results suggest that the up-regulation of laminin, especially gamma1 subunit of laminin, in human nasal polyps might be one of the most important cause of the development of nasal polyp. However, we did not able to identify a mechanism of the reduction of nasal polyps by the indomethacin.