Molecular mechanism of cell adhesion and cell migration in gingival junctional epithelium.
Molecular mechanism of cell adhesion and cell migration in gingival junctional epithelium.
批准号:
19592134
负责人:
SHIMONO Masaki
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
本研究的目的是检测层粘连蛋白γ_2、整合素β_4和整合素α_3在正常和再生牙龈结合上皮中的表达,以了解创伤愈合和细胞迁移的机制。我们的结果提示,结缔组织中层粘连蛋白γ_2的分泌可能诱导上皮细胞迁移,而层粘连蛋白γ_2与IBL中整合素α_6β_4和整合素α_3β_1的结合可能会引起面向牙齿的细胞在再生连接上皮釉表面的黏附和迁移。
英文摘要
The aim of this study was, examine the expression of laminin γ_2, integrin β_4 and integrin α_3 in the normal and regenerating gingival junctional epithelium in order to understand the mechanism of wound healing and function of cell migration. Our results suggest that secretion of laminin γ_2 in the connective tissue may induce epithelial cell migration, and that binding of laminin γ_2 to integrin α_6β_4 and integrin α_3β_1 in the IBL may provoke cell adhesion and migration of cells facing the tooth on the enamel surface of the regenerating junctional epithelium.
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会议论文
新口腔病理学
新口腔病理学
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Kawakami T, Kaneko K, Takaya T, Aoki S, Muraoka R, Tomida M, Okafuji N, Shoumura M, Osuga N, Nakano K, Tsujigiwa H, Nagatuka H., 長塚 仁,中野敬介]
通讯作者:
長塚 仁,中野敬介
MOLECULAR MECHANISMS OF HOMEOSTASIS AND MECHANICAL STRESS-RESPONSE IN PERIODONTAL LIGAMENT
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批准号:13470389
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.9万
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财政年份:2001
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负责人:SHIMONO Masaki
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依托单位:
Comprehensive study of root surface treatment and regeneration in periodontal disease
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批准号:10557202
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.06万
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财政年份:1998
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负责人:SHIMONO Masaki
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依托单位:
Molecular Mechanism and Signal Transduction for Salivary Secretion
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批准号:07407051
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$17.98万
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财政年份:1995
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负责人:SHIMONO Masaki
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依托单位:
Regulatory mechanism of cell differentiation and functional manifestation in the dental pulp.
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批准号:04454455
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.22万
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财政年份:1992
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负责人:SHIMONO Masaki
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依托单位:
Interrelationship between epithelial and connective tissue attachments during wound healing of the periodontal tissues.
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批准号:02670815
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1990
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负责人:SHIMONO Masaki
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依托单位:
An Experimental Study on the Biological Property of Periodontal Pocket-epithelium.
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批准号:62570814
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1987
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负责人:SHIMONO Masaki
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依托单位:
海外基金