Effects of opioids and supplementary analgesics on the accumbal catecholaminergic activity

起源于腹侧被盖区的多巴胺能神经元终止于伏核。阿片类药物奖赏效应的具体机制尚不清楚，但幻象行为学研究表明，伏核多巴胺能活动的增强起着重要作用。因此，本研究采用在体脑微透析技术，探讨了自由活动大鼠伏隔区多巴胺外流增加的机制。我们还研究了伏核中去甲肾上腺素和多巴胺的相互作用以及纹状体细胞外释放多巴胺的细胞内来源。

Dopaminergic neurons, which arise in the ventral tegmental area terminate among others in the nucleus accumbens. The detailed mechanisms of rewarding effects of opioids remain unclear, but the phanmaco-behavioural studies suggest that enhance of accumbal dopaminergic activity plays a significant role. Therefore, in the present study, we investigated the mechanisms of the increase of accumbal dopamine efflux in freely moving rats, using the in vivo brain microdialysis technique。 We also studied the noradrenaline-dopamine interaction in the nucleus accumbens and the intracellular origin of extracellulary released striatal dopamine.