Epidemiology of knee osteoarthritis, lumbar spondylosis and osteoporosis in Japanese men and women : The Research on Osteoarthritis/osteoporosis Against Disability(ROAD)

肌肉骨骼疾病，包括骨关节炎和骨质疏松症，是老年人的主要公共卫生问题，影响他们的日常生活能力和生活质量，导致发病率和死亡率增加。由于日本日益老龄化的人口，迫切需要一个全面和循证的预防骨关节系统疾病的策略，包括骨关节炎和骨关节疾病。然而，到目前为止，只进行了几项前瞻性的纵向研究，关于日本人群中OA和OP的患病率和发病率的信息很少。没有这样的流行病学数据，很难设计出合理的临床和公共卫生方法来诊断、评估和预防骨性关节炎和骨质疏松症。因此，我们建立了一个全国性的大规模骨性关节炎/骨质疏松症抗残疾队列研究(ROAD)，该研究由3个社区…的3040名参与者组成更多的ES位于日本的城市、山区和沿海地区(基线研究)。膝关节骨性关节炎和腰椎滑脱症的放射学分级为。2按Kellgren-Lawrence量表计算。OP是由日本骨矿研究学会的标准来定义的。使用基线数据，我们估计男性和女性膝骨性关节炎的患病率为42。0%和61%。5%，男性和女性腰椎骨关节炎分别为80%和80%。6%和61%。男女L2-4OP分别为3.4%和19.2%，股骨颈OP男女分别为12.4%和26%。分别为5%。在日本，KOA、LS、L2-4和股骨颈OP患者的估计数量分别约为2500万、3800万、640万和1100万。在基线研究之后，2008年至2010年在同一社区进行了第二次调查，调查对象包括2674名居民。考虑到大约3.3年的随访，KL的发生率。2膝关节骨密度男性为2.1%/年，女性为3.6%/年。类似地，KL的发病率。2X线片LS男性为15.3%/年，女性为10.5%/年。较少

Musculoskeletal diseases, including osteoarthritis(OA) and osteoporosis(OP), are major public health problems among the elderly that affect their activities of daily living(ADL) and quality of life(QOL), leading to increased morbidity and mortality. Because of the growing aging population in Japan, a comprehensive and evidence-based strategy for the prevention of diseases of bone and joint system, including OA and OP, is urgently required. However, only a few prospective longitudinal studies have been undertaken thus far, and little information is available on the prevalence and incidence of OA and OP in the Japanese population. It is difficult to design rational clinical and public health approaches for the diagnosis, evaluation, and prevention of OA and OP without such epidemiological data.We, therefore, established a large-scale nationwide OA/OP cohort study titled Research on Osteoarthritis/osteoporosis against Disability(ROAD), which consisted of 3, 040 participants in 3 communiti … More es located in the urban, mountainous, and coastal areas(baseline study) of Japan. KOA and LS were radiographically defined as a grade of. 2 by the Kellgren-Lawrence scale. OP was defined by the criteria of the Japanese Society for Bone and Mineral Research. Using the baseline data, we estimated the prevalence of knee OA in men and women was 42. 0% and 61. 5%, respectively, that of lumbar OA in men and women was 80. 6% and 61. 5%, that of L2-4 OP in men and women was 3. 4% and 19. 2%, and that of femoral neck OP in men and women was 12. 4% and 26. 5%, respectively. The estimated number of patients with KOA, LS, L2-4 and femoral neck OP in Japan was approximately 25, 38, 6. 4 and 11 million, respectively. Following the baseline study, a second survey was performed in the same communities between 2008 and 2010, comprising of 2, 674 inhabitants. Given the approximately 3. 3-year follow-up, incidence of KL. 2 radiographic knee OA was 2. 1%/yr and 3. 6%/yr in men and women, respectively. Similarly, incidence of KL. 2 radiographic LS was 15. 3%/yr and 10. 5%/yr in men and women, respectively. Less