Epidemiology of knee osteoarthritis, lumbar spondylosis and osteoporosis in Japanese men and women : The Research on Osteoarthritis/osteoporosis Against Disability(ROAD)

肌肉骨骼疾病，包括骨关节炎（OA）和骨质疏松症（OP），是影响老年人日常生活活动（ADL）和生活质量（QOL）的主要公共卫生问题，导致发病率和死亡率增加。由于日本人口老龄化日益严重，迫切需要一种全面的、循证的骨关节系统疾病预防策略，包括OA和OP。然而，到目前为止，只有少数前瞻性纵向研究进行，并且很少有关于日本人群中OA和OP的患病率和发病率的信息。没有这些流行病学数据，很难设计合理的临床和公共卫生方法来诊断、评估和预防OA和OP。因此，我们建立了一项大规模的全国性OA/OP队列研究，名为“骨关节炎/骨质疏松症对残疾的研究”（ROAD），该研究包括来自日本城市、山区和沿海地区（基线研究）的3个社区的3040名参与者。KOA和LS放射学定义为等级。根据kelgren - lawrence量表，是2。OP是根据日本骨与矿物研究协会的标准定义的。使用基线数据，我们估计男性和女性膝关节OA的患病率为42%。0%和61。男性和女性腰骨关节炎患病率分别为80。6%和61。l4 -4 OP在男女中分别为3%。4%和19。男性和女性股骨颈OP的发生率分别为2%和12%。4%和26。5%,分别。在日本，KOA、LS、L2-4和股骨颈OP患者的估计数量约为25,38,6。分别是400万和1100万。在基线研究之后，2008年至2010年在同一社区进行了第二次调查，其中包括2674名居民。已知近似的3。随访3年，膝关节骨性关节炎的发病率为2。1%/年和3。男性和女性分别为6%/年。同样，kl2 x线片LS的发生率为15。每年3%和10。男性和女性分别为5%/年。少

Musculoskeletal diseases, including osteoarthritis(OA) and osteoporosis(OP), are major public health problems among the elderly that affect their activities of daily living(ADL) and quality of life(QOL), leading to increased morbidity and mortality. Because of the growing aging population in Japan, a comprehensive and evidence-based strategy for the prevention of diseases of bone and joint system, including OA and OP, is urgently required. However, only a few prospective longitudinal studies have been undertaken thus far, and little information is available on the prevalence and incidence of OA and OP in the Japanese population. It is difficult to design rational clinical and public health approaches for the diagnosis, evaluation, and prevention of OA and OP without such epidemiological data.We, therefore, established a large-scale nationwide OA/OP cohort study titled Research on Osteoarthritis/osteoporosis against Disability(ROAD), which consisted of 3, 040 participants in 3 communiti … More es located in the urban, mountainous, and coastal areas(baseline study) of Japan. KOA and LS were radiographically defined as a grade of. 2 by the Kellgren-Lawrence scale. OP was defined by the criteria of the Japanese Society for Bone and Mineral Research. Using the baseline data, we estimated the prevalence of knee OA in men and women was 42. 0% and 61. 5%, respectively, that of lumbar OA in men and women was 80. 6% and 61. 5%, that of L2-4 OP in men and women was 3. 4% and 19. 2%, and that of femoral neck OP in men and women was 12. 4% and 26. 5%, respectively. The estimated number of patients with KOA, LS, L2-4 and femoral neck OP in Japan was approximately 25, 38, 6. 4 and 11 million, respectively. Following the baseline study, a second survey was performed in the same communities between 2008 and 2010, comprising of 2, 674 inhabitants. Given the approximately 3. 3-year follow-up, incidence of KL. 2 radiographic knee OA was 2. 1%/yr and 3. 6%/yr in men and women, respectively. Similarly, incidence of KL. 2 radiographic LS was 15. 3%/yr and 10. 5%/yr in men and women, respectively. Less