Study on the mechanisms by which functional foods regulate androgen receptor function

雄激素受体调节与前列腺癌增殖和进展有关的一些基因的表达。在本研究中，我们确定了缺氧诱导因子-1a （HIF-1a）和b-catenin在缺氧条件下作为协同AR共激活因子，并展示了这些共激活因子增强AR转激活的分子机制。此外，我们基于分子机制构建了雄激素和抗雄激素化合物的酵母快速生物测定方法，并分析了食品成分的抗雄激素活性。

Androgen receptor regulates the expression of some genes involved in proliferation and progression of prostate cancer. In the present study, we identified hypoxia-inducible factor-1a (HIF-1a) and b-catenin as cooperative AR coactivators under hypoxic conditions and demonstrated the molecular mechanisms by which these coactivators enhanced AR transactivation. Furthermore, we constructed a rapid yeast bioassay for androgenic and anti-androgenic compounds based on the molecular mechanisms and analyzed anti-androgenic activity of food components.