Targeted therapy for defect of fertilizing ability in the spermatozoa from subfertile livestock

动物繁殖的第一步是完成体内受精。为了成功受精，精子需要在其受精能力的发挥过程中表现出精确的过程。在这项研究中，我们指出细胞内信号和葡萄糖代谢的关键调节因子是抑制精子中与早熟受精相关的事件的潜在靶点。此外，我们还认为顶体蛋白酪氨酸残基的磷酸化缺陷是导致不育雄性动物精子结构不稳定的原因之一。

The initial step of animal reproduction is accomplishment of in vivo fertilization. For the purpose of successful fertilization, spermatozoa are required to show a precise process in the exertion of their fertilizing ability. In this study, we indicated that pivotal regulators of the intracellular signaling and glucose metabolism are potential targets to suppress precocious fertilization-related events in the spermatozoa. In addition, we also suggested that defective phosphorylation at the tyrosine residues of acrosomal proteins is one of causal factors for unstable structure in the spermatozoa from subfertile male animals.