Making and clinical application of supporting software for the optimal administration method of drug based on the PK/PD theory on the target-organ

我们制作了一套新的系统，用于在我们的研究合作医院采集患者的血液和生物样本。建立了患者送药样品的药物浓度测定方法。药物浓度测定结果通过电子邮件发送给研究合作医院。采集每位患者药物的药代动力学（PK）和药效学（PD）数据。根据收集到的个体药代动力学数据估算群体药代动力学参数（PPK）。基于估算PPK所使用的靶器官的PK/PD理论，制作了药物最优给药方法的配套软件。

We made a new system which collected blood and biological samples in patient at our research collaboration hospitals. It established the drug concentration measurement methods of those delivered samples of patients. Those measured drug concentration results were sent to the research collaboration hospitals by e-mail. It collected the pharmacokinetic (PK) and the pharmacodynamics (PD) data of drug in each patient. It estimated the population pharmacokinetic parameter (PPK) from the gathered individual PK data. We made the supporting software for the optimal administration method of drug based on the PK/PD theory on the target-organ used by the estimated PPK.