Studies on the role of endogenous digitalis in electrolytes and blood pressure regulation

在各种内源性洋地黄中，最初在蟾蜍中发现，现在在人类中发现的蟾二烯内酯已被证明具有具有生物功能的毒素类型。它们随着钠的增加而增加。用来自肾上腺皮质、髓质和下丘脑神经元的永生化细胞系测定了这两种物质的来源和分泌机制，发现它们具有活性。结合我们之前的研究，我得出结论：钠代谢在所有类型高血压的发病机制中都起着至关重要的作用；因此，脑肾素-血管紧张素-醛固酮系统和乌巴因本质上是参与者。

Among a variety of endogenous digitalis, bufadienolides originally found in toads and now determined in humans were demonstrated to have their toxin types with biological functions. They increase with sodium-loading. Immortalized cell lines originated from adrenal-cortex and -medulla, and hypothalamic neurons were used to determine the origin and secretory mechanism of those bufadienolides and ouabain, and the active production was found. Collectively with our previous studies, I conclude that sodium metabolism is crucially involved in the pathogenesis of all types of hypertension ; thereby, brain renin-angiotensin-aldosterone system and ouabain are essentially implicated as players.