Elucidation of the molecular mechanism leading to the dysplasia of blood cells in the myelodysplastic syndromes

为了阐明骨髓增生异常综合征（MDS）患者血细胞异常增殖的分子机制，我们研究了来那度胺对MDS-L细胞系染色体5 q缺失的影响。结果，MDS-L细胞显示胞质分裂的抑制和细胞周期相关基因的基因表达的减少，包括位于染色体5 q的KIF 20 A。RNA干扰研究表明，抑制KIF 20 A的表达会影响血细胞的生长和形态。

Aiming at the elucidation of the molecular mechanism leading to the dysplasia of blood cells in the myelodysplastic syndromes, we studied the effect of lenalidomide on MDS-L cell line which shows a deletion of chromosome 5q. As a result, MDS-L cells revealed an inhibition of cytokinesis and a reduction of gene expression of cell cycle-related genes including KIF20A which was located at chromosome 5q. RNA interference study suggested that inhibition of KIF20A expression affects the growth and morphology of blood cells.