Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican Children

标题：H的流行。多米尼加儿童幽门螺杆菌感染与慢性萎缩性胃炎的关系pylori感染和慢性萎缩性胃炎（CAG）及CagA抗体阳性。pylori感染的可能性，并探讨与H. pylori感染和CAG的多变量analysis.METHODS：1031名受试者谁给了我们的书面知情同意书是从幼儿园，幼儿园，小学和初中在多米尼加共和国的儿童志愿者。所有受试者均接受健康检查，并采集血样测定血清胃蛋白酶原I和II、胃蛋白酶原I/II比值、血清胃泌素、H。pylori抗体和抗H. pylori感染率，并对上消化道疾病进行问卷调查。pylori感染（0.000-0.467）和CAG（0.000-0.158）随年龄和性别而变化。C的正性 ...更多信息 阿加抗体。在多米尼加儿童中，随着年龄的增长，男孩和女孩的H. pylori感染率也随之增加。pylori感染情况采用前向似然法进行逐步回归分析，选择H. pylori感染作为因变量。该模型包括25个自变量（胃肠道疾病相关的主观症状、既往史、家族史、环境、生活方式、性别和年龄、受检者资料;血清胃泌素水平）。在逻辑回归模型的最后一步，没有H。pylori感染的正确分类率为93.5%。H. pylori感染的正确分类率为27.7%。总体而言，75.6%的受试者被正确分类。H.男性pylori感染率是女性的1.465。H. pylori感染率随年龄增加而增加，年龄增加1岁时pylori感染率为1.326。H. pylori感染率每增加1人为1.185。H.以腹泻为自觉症状者pylori感染率为1.567。H. pylori感染率为1.008。为明确慢性萎缩性胃炎（CAG）的相关因素，以慢性萎缩性胃炎（CAG）为因变量，采用前向似然法进行逐步回归分析。模型包括9个自变量（胃肠道疾病相关的主观症状、既往史、家族史、环境、生活方式、性别、年龄、受检者资料、血清胃泌素水平、H. pylori感染及抗H. pylori）。在逻辑回归模型的最后一步，在没有CAG的受试者中，99.0%被正确分类。在CAG患者中，18.5%被正确分类。总体而言，88.0%的受试者被正确分类。当受试者血清胃泌素水平升高1 pg/ml时，CAG的优势比为1.006。抗H. pylori感染率为2.090。H. pylori感染率为2.738。pylori感染的性别交叉表。pylori感染和抗H. pylori检测结果显示，CagA抗体阳性率在男女生之间无显著性差异。然而，用我们的CagA检测试剂盒检测无H.结论：血清胃泌素、抗H. pylori和H.幽门螺杆菌感染是CAG的良好标志物，即使在儿童中也是如此。目的：探讨H. pylori与慢性萎缩性胃炎的关系有待进一步研究。少

TITLE : Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican ChildrenPURPOSE : To show the prevalence of H. pylori infection and chronic atrophic gastritis (CAG) and the positivity of CagA antibody to H. pylori in the Dominican children, and to clarify the several factors that related to H. pylori infection and CAG by multivariate analysis.METHODS : One thousand and thirty one subjects who have given us the informed consent in writing were volunteers from children of the nursery school, a kindergarten, a primary school, and a junior high school in the Dominican Republic. Each individual underwent a health checkup and blood sampling for measurement of serum pepsinogen I and II, pepsinogen I/II ratio, serum gastrin, H. pylori antibodies, and CagA antibody to H. pylori, and responded to a questionnaire on upper digestive tract diseases.RESULTS : The prevalence of H. pylori infection (0.000-0.467) and CAG (0.000-0.158) varied by age and sex. The positivity of C … More agA antibody to H. pylori for boys and girls increased by advancing age in the Dominican children.To show the factors related to be H. pylori infection was done the stepwise regression analysis using forward likelihood procedure and choosing H. pylori infection as the dependent variable. The model included twenty-five independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender and age, and subjects examined data ; serum gastrin level. In this final step of the logistic regression model, of the subjects without H. pylori infection, 93.5% were correctly classified. Of the subjects with H. pylori infection, 27.7% were correctly classified. Overall, 75.6% of all subjects were correctly classified. The odds ratio of H. pylori infection in male subjects was 1.465 to female subjects. The odds ratio of H. pylori infection was 1.326 when age of the subject increase one year old. The odds ratio of H. pylori infection was 1.185 when numbers of children who live together increase one person. The odds ratio of H. pylori infection in subjects with diarrhea as subjective symptom was 1.567 to those without diarrhea. The odds ratio of H. pylori infection was 1.008 when serum gastrin level of the subject increases 1 pg/ml.To clarify the factors related to be chronic atrophic gastritis (CAG) was done the stepwise regression analysis using forward likelihood procedure and choosing chronic atrophic gastritis (CAG) as the dependent variable. The model included nine independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender, and age, subjects examined data; serum gastrin level, H. pylori infection, and antibody of CagA to H. pylori). In this final step of the logistic regression model, of the subjects without CAG, 99.0% were correctly classified. Of the subjects with CAG, 18.5% were correctly classified. Overall, 88.0% of all subjects were correctly classified. The odds ratio of CAG was 1.006 when serum gastrin level of the subject increased 1 pg/ml. The odds ratio of CAG in subjects with antibody of CagA to H. pylori infection was 2.090 to those without antibody of CagA. The odds ratio of CAG in subjects with H. pylori infection was 2.738 to those without H. pylori infection.The Cross tabulation by gender between H. pylori infection and antibody of CagA to H. pylori showed it that the positivity of CagA antibody has not seen significant differences between boys and girls. However, the positivity of CagA antibody was about 20 % by our CagA measurement kit in subjects1 who have had no H. pylori infection.CONCLUSIONS :Our results indicated that serum gastrin, CagA antibody to H. pylori, and H. pylori infection are a good marker of CAG even in children. To clarify the relationship between the positivity of CagA antibody to H. pylori and chronic atrophic gastritis need further study. Less