The role of retinoic acid in pituitary tumorigenesis

脑下垂体前叶分泌六种荷尔蒙，这些荷尔蒙对维持生长、繁殖和动态平衡至关重要。本研究旨在阐明维甲酸(RA)与垂体肿瘤发生的关系。我证明了雌激素诱导的催乳素瘤模型大鼠的RA合成酶降低，这种作用是通过雌激素受体α介导的。此外，RA对垂体前叶细胞中几个基因的表达也有影响。希望这些结果有助于阐明肿瘤的发生机制和肿瘤的治疗。

The anterior pituitary gland secrets six types of hormones, which are crucial to maintain growth, reproduction, and homeostasis. The purpose of this study is to clarify the relationship between retinoic acid (RA) and tumorigenesis of pituitary. I demonstrated that RA synthesizing enzyme was reduced in estrogen-induced prolactinoma model rats, and that the effect was mediated by estrogen receptor alpha. In addition, RA exerted effects on several genes expression in the anterior pituitary cells. It is hoped that these results contribute to elucidating the neoplasia mechanism and tumor therapy.