Effects of activation of oxytocin receptor in neonatal brain on the development of mother-infant attachment.

母体分离诱导了小鼠视上核内催产素产生神经元的激活。新生儿期注射催产素受体拮抗剂可调节成年后的焦虑相关行为和社会行为。另一方面，为了检测分娩时催产素释放增加对胎儿大脑的影响，我们调查了剖宫产小鼠的行为。与自然分娩的小鼠相比，剖腹产后注射催产素的小鼠表现出更多的焦虑相关行为。这些结果表明，在母婴互动或分娩过程中，新生儿大脑中催产素受体的激活会影响成年后的情绪和社会行为。

Maternal separation induced the activation of oxytocin-producing neurons in the supraoptic nucleus of mouse pups. Injection of oxytocin receptor antagonist in the neonatal period modulated anxiety-related and social behaviors in adulthood. On the other hand, to examine effects of increased oxytocin release at parturition upon fetal brain, we investigated the behavior of mice delivered by Cesarean section. Mice delivered by Cesarean section and then injected with oxytocin exhibited increased anxiety-related behavior as compared to mice delivered naturally. These results suggest that the activation of oxytocin receptor in neonatal brain during mother-infant interaction or parturition affects emotional and social behaviors in adulthood.